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Box-Behnken响应面法结合多指标综合评分法优选柴胡安心胶囊的水提工艺

Optimization of Water Extraction Technology of Chaihu Anxin Capsules by Box-Behnken Response Surface Method Combined with Multi-index Comprehensive Scoring Method

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【作者】 王玲娇郝玉佩刘坤申杨继章孙国祥于静

【Author】 WANG Lingjiao;HAO Yupei;LIU Kunshen;YANG Jizhang;SUN Guoxiang;YU Jing;Dept.of Pharmacy,the First Hospital of Hebei Medical University;Dept.of Cardiology,the First Hospital of Hebei Medical University;College of Pharmacy, Shenyang Pharmaceutical University;

【通讯作者】 于静;

【机构】 河北医科大学第一医院药学部河北医科大学第一医院心内科沈阳药科大学药学院

【摘要】 目的:优化柴胡安心胶囊的水提工艺。方法:以提取液中没食子酸、绿原酸、葛根素、大豆苷、芦丁、肉桂酸、槲皮素的含量和出膏率的综合评分值为考察指标,以加液倍数、浸泡时间、回流时间、提取次数为因素,在单因素试验基础上运用Box-Behnken响应面法对柴胡安心胶囊的水提工艺进行优化并进行验证试验。结果:最优提取工艺为加11倍水、浸泡10 h,提取2次,每次回流1.5 h;验证试验中3批样品提取后的综合评分值(91.37%)与预测值(91.38%)相比较,相对误差为1.87%(RSD<2%,n=3)。结论:优选的提取工艺方法简单、结果稳定,可用于后续柴胡安心胶囊的制剂生产。

【Abstract】 OBJECTIVE: To optimize the water extraction technology of Chaihu anxin capsules. METHODS: Taking comprehensive scoring value of the contents of gallic acid,chlorogenic acid,puerarin,glycoside,rutin,cinnamic acid,quercetin and the yield of extract as investigation index,using multiple of adding liquid,soaking time,reflux time and extraction times as factors,water extraction technology of Chaihu anxin capsule was optimized by Box-Behnken response surface method based on single factor test. Validation test was conducted. RESULTS:The optimal extraction technology of Chaihu anxin capsules was adding 11 times of water,soaking for 10 h,extracting for 2 times,refluxing for 1.5 h each time. In validation test,the relative deviation of comprehensive scoring value to predicted value was 1.87% for 3 batches of samples(RSD<2%, n=3).CONCLUSIONS:The optimal extraction technology is simple,stable and suitable for further production of Chaihu anxin capsules.

【基金】 国家自然科学基金资助项目(No.81573586);河北省中医药管理局科研计划项目(No.2018117)
  • 【分类号】R286
  • 【被引频次】2
  • 【下载频次】320
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