【摘要】 特发性矮身材(idiopathic short stature,ISS)是儿童矮身材中最常见的类型,其发病机制尚不明确。尽管ISS可应用生长激素治疗,但是疗效有限,这促使临床医生不断探究ISS的病因。近来研究显示ISS病因与内分泌、信息传递途径的缺陷及其相关基因的突变等因素有关,现总结为以下几点:生长激素-胰岛素样生长因子1(GH-IGF-1)轴及相关基因;软骨生长板的相关基因及激素;其他相关因素。本文就近几年ISS病因研究进展作一综述。更多还原

【Abstract】 Idiopathic short stature(ISS) is the most common type in children with short stature, and its pathogenesis is unclear. Although ISS can be treated with growth hormone, its efficacy is limited, which has prompted clinicians to further explore the etiology of ISS. Recent studies have shown that the etiology of ISS is related to endocrine, defect of information transmission pathway and mutation of related genes, which are summarized as follows: growth hormone-insulin-like growth factor 1(GH-IGF-1) axis and related genes, the related genes and hormones of the cartilage growth plate and other relevant factors. This article reviews the etiology of ISS in recent years.更多还原