【摘要】 目的探讨T2DM患者早相胰岛素分泌与颈动脉粥样硬化(CAS)及UAlb的关系。方法选取2017年1月至2018年12月于我院内分泌科住院的T2DM患者333例,根据早相胰岛素分泌指数(IGI30)水平分为低、中、高组,应用彩色多普勒超声检测颈动脉内中膜厚度(CIMT)及粥样硬化斑块,测定HbA1c、TC、UACR等生化指标,行OGTT试验测定FPG、FC-P、餐后血糖及C-P等。分析各组生化指标,以CAS、UAlb为因变量,将IGI30、IGI120及HOMA2-IR纳入Logistic回归模型进行分析。结果各组CIMT、UAlb发生率差异无统计学意义,IGI30低、中、高组UACR、CAS发生率依次降低[11. 90(3. 05,71. 96)vs 5. 10(2. 10,18. 00)vs 2. 92(1. 26,8. 46)mg/g,56. 76%vs 43. 24%vs31. 53%;P<0. 05]。校正年龄、性别、糖尿病病程等因素后,Logistic回归分析结果显示,IGI30、HOMA2-IR是CAS、UAlb的影响因素。结论 T2DM患者早相胰岛素分泌功能下降与CAS及UAlb密切相关。更多还原

【Abstract】 ObjectiveTo investigate the correlation between early phase insulin release and carotid atherosclerosis(CAS)and urinary microalbumin(UAlb)in patients with type 2 diabetes(T2 DM).333 T2 DM patients were included in this study. The intima-media thickness of carotid artery(CIMT)and the presence of atherosclerotic plaques were measured by Doppler ultrasonography. The laboratory data were collected such as glycated hemoglobin(HbA1 c),total cholesterol(TC)and urinary microalbumin creatinine ratio(UACR). The fasting and postprandial plasma glucose,fasting and postprandial C-peptide were tested via oral glucose tolerance test(OGTT). These patients were divided into low IGI30 group,middle IGI30 group and high IGI30 group according to the levels of IGI30. Logistic regression models were used to analyze the factors affecting carotid atherosclerosis and UAlb.cant difference in the incidence of CIMT and UAlb in each group. The incidence of UACR and CAS gradually decreased in low,medium and high IGI30 group[11. 90(3. 05,71. 96)vs 5. 10(2. 10,18. 00)vs 2. 92(1. 26,8. 46)mg/g,56. 76% vs 43. 24% vs 31. 53%;P<0. 05]. After adjusting for age,gender,course of disease and other factors,Logistic regression analysis showed that IGI30 and HOMA2-IR were the influencing factors of CAS and UAlb.rence of CAS and UAlb in T2 DM patients.更多还原