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运动对存在黎明现象的2型糖尿病患者血糖及血糖波动影响的观察

Effects of moderate intensity aerobic exercise on blood glucose and blood glucose fluctuation in type 2 diabetes patients with dawn phenomenon

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【作者】 郑欣张燕戚艳艳毕丽娜赵丹胡苏

【Author】 ZHENG Xin;ZHANG Yan;QI Yanyan;Department of Endocrinology,China Rehabilitation Research Center;

【通讯作者】 张燕;

【机构】 中国康复研究中心内分泌科

【摘要】 目的探讨存在黎明现象的T2DM患者在早餐前进行中等强度有氧运动后血糖水平、血糖波动情况的变化。方法选取2018年1~8月于中国康复研究中心内分泌科住院,经动态血糖监测(CGMS)后明确存在黎明现象的13例T2DM患者,进行相关数据分析,测定相关生化指标,留取基础数据后再次进行CGMS,并于早餐前进行30 min中等强度跑台训练,分析运动前后黎明时血糖水平和波动情况。结果受试者BMI、HbA1c、HOMA-IR水平高于正常范围,HOMA-β低于正常范围。与运动前比较,运动后的早餐前血糖[(7.82±0.76) vs (8.73±1.13) mmol/L]、黎明时血糖上升幅度[(1.57±0.46)vs (2.49±1.17) mmol/L]、血糖平均值[(7.81±0.89) vs (8.60±0.98) mmol/L]、血糖标准差[(1.41±0.60) vs (1.86±0.67) mmol/L]、血糖变异系数[(17.89±6.53)%vs (21.72±7.82)%]、平均血糖波动幅度[(3.73±1.97) vs (4.89±2.19)mmol/L]均降低(P<0.05)。结论早餐前进行中等强度有氧运动,可降低存在黎明现象的T2DM患者黎明时血糖上升幅度,减少血糖波动,改善黎明现象。

【Abstract】 Objective To investigate the effects of moderate intensity aerobic exercise before breakfast on blood glucose levels and blood glucose fluctuations in type 2 diabetes patients(T2DM) with dawn phenomenon.Methods A total of 13 T2DM in-patients with dawn phenomenon were recruited from January to August 2018.After a regular CGM monitoring,subjects was asked for a 30 min moderate intensity aerobic exercise with CGM monitoring.The blood glucose level and blood glucose fluctuation at dawn before and after exercise were analyzed.Results Subjects in this study had higher BMI,HbA1 c and HOMA-IR and lower HOMA-β.After a 30 min moderate intensity aerobic exercise,the maximum value of blood glucose before breakfast [(7.82±0.76) vs(8.73±1.13) mmol/L],the magnitude of blood glucose rise at dawn [(1.57±0.46) vs(2.49±1.17) mmol/L],the average value of blood glucose [(7.81±0.89)vs(8.60±0.98) mmol/L],standard deviation of blood glucose [(1.41±0.60) vs(1.86±0.67) mmol/L],the coefficient of blood glucose variation [(17.89±6.53)% vs(21.72±7.82)%] and the mean amplitude of glycemic excursion [(3.73±1.97) vs(4.89±2.19) mmol/L] were lower than before exercise(P<0.05).Conclusion Moderate intensity aerobic exercise before breakfast can reduce the blood glucose fluctuations and improve the dawn phenomenon in T2DM patients.

【基金】 中央级公益性科研院所基本科研业务费专项资金(2014CZ-26)
  • 【文献出处】 中国糖尿病杂志 ,Chinese Journal of Diabetes , 编辑部邮箱 ,2019年10期
  • 【分类号】R587.1
  • 【被引频次】5
  • 【下载频次】253
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