【摘要】 流行病学研究表明,环境砷暴露与糖尿病相关,但其机制并未得到证实。砷毒性可能与表观遗传调控有关,砷暴露可引起糖尿病的相关基因表达发生改变,进而影响下一代的生长发育,但并未引起遗传信息改变。本文从DNA甲基化、组蛋白修饰和miRNA改变共3个方向对砷导致糖尿病的可能机制进行综述。更多还原

【Abstract】 Epidemiological studies have shown that environmental arsenic exposure is associated with diabetes. However, the exact mechanism of arsenic-induced diabetes has not been confirmed. In recent years, a large number of studies have shown that arsenic toxicity may be related to epigenetic regulation mechanisms. Arsenic exposure may cause changes in the expression of diabetes-related genes, which in turn affects the growth and development of the next generation, but does not cause changes in the genetic information of next generation. Thus, the possible mechanisms of arsenic-induced diabetes will be explored from three aspects: DNA methylation, histone modification and miRNA alteration.更多还原