【摘要】 采用热高压均质法制备用于封装、保护并提供白藜芦醇和亚麻籽油的纳米结构脂质载体(RL-NLC),并进行微观形貌、理化稳定性、抗氧化性、体外释放、脂质加速氧化等特性的表征研究。制备的RL-NLC粒径约为105 nm,多分散指数(PDI)约为0.216。该球形纳米颗粒在水溶液中分散性良好,25℃避光条件下能储存3个月以上。载体化后的白藜芦醇具有更好的抗氧化活性和缓慢的体外释放速度。在50℃加速储存试验中,固化的脂质核和白藜芦醇的存在共同抑制了亚麻籽油的氧化。本文开发的白藜芦醇和亚麻籽油复配载体,可能在功能食品领域具有良好的应用前景。更多还原

【Abstract】 The nanostructured lipid carrier(RL-NLC) was developed to encapsulate, protect and deliver resveratrol and linseed oil by the hot high pressure homogenization technology. The microstructure, physicochemical stability, antioxidant activity, in vitro release, accelerated lipid oxidation and other characteristics were analyzed. The particle size of RL-NLC was about 105 nm and the PDI was about 0.216. The spherical nanoparticles could be well dispersed in aqueous and could be stored for more than 3 months at 25 ℃ without light. Encapsulated resveratrol had better antioxidant activity and slower release rate in vitro than free resveratrol. In addition, it was found that the presence of the solid lipid core and resveratrol inhibited the oxidation of linseed oil in an accelerated storage experiment at 50 ℃. The carrier loaded resveratrol and linseed oil developed in this paper may have a good application prospect in the field of functional foods.更多还原