【摘要】 目的探讨山西省子宫颈上皮内瘤变(CIN)队列中HPV感染的分布特点及其高危因素。方法对2014年6—12月山西地区<65岁已婚女性40 000例行宫颈癌筛查,排除宫颈液基细胞学(TCT)示腺细胞异常者,进一步行阴道镜检查和组织病理学检查,最终共2304例女性纳入研究。采用调查问卷收集人口学特征及子宫颈癌相关因素情况,采用导流杂交术进行HPV分型检测。结果 HPV高感染年龄段为36~40岁;HPV感染率居前5位型别分别为HPV16、58、52、53、51。CIN2及以上中HPV感染率居前5位型别分别为HPV16、58、31、33、52。HPV单一感染占23.13%,多重感染占9.51%,且随着宫颈病变程度增加,HPV单一感染率及多重感染率也随之增加。多因素分析结果显示:受教育年限≤9年者感染HPV的风险是>9年者的1.236倍(95%CI 1.029~1.484);非经期使用护垫者感染HPV的风险是不使用护垫者的1.328倍(95%CI 1.016~1.736);未绝经女性感染HPV的风险是绝经女性的2.407倍(95%CI 2.012~2.880)。结论山西省HPV感染高发年龄段为36~40岁;HPV感染最常见的型别为HPV16、58、52、53、51;致病性较强的型别为HPV16、58、31、33、52,其分布特点不同于其他地区;受教育年限短、未绝经、非经期使用护垫是HPV感染的高危因素。更多还原

【Abstract】 Objective To investigate the distribution characteristics and risk factors of HPV infection in the cervical intraepithelial neoplasia(CIN)cohort in Shanxi Province.Methods From June to December 2014,40,000 married women under the age of 65 years in Shanxi were screened for cervical cancer,and the abnormal cervical fluid-based cytology(TCT)was excluded.Gland microscopy and histopathological examination were performed.Finally a total of 2304 women were included in the study.Questionnaires were used to collect demographic characteristics and factors related to cervical cancer,and HPV typing was performed by flow-through hybridization.Results Among the 2304 subjects,the HPV infection age range was 36-40 years old;the top 5 HPV infection rates were HPV16/58/52/53/51.The top 5 HPV infectionrates in CIN2 及 以 上 were HPV16/58/31/33/52. HPV single infection accounted for 23.13%,multiple infection accounted for 9.51%,and with the increase of cervical lesion,degree HPV single infection rate and multiple infection rate also increased.Multivariate analysis showed that the risk of HPV infection in those who were educated for ≤ 9 years was 1.236 times(95% CI 1.029-1.484)of those who were educated for >9 years;the risk of HPV infection in the women with non-menstrual use of pads was 1.328 times(95% CI 1.016～1.736)of menopausal women,the risk of HPV infection in non-menopausalwomen was 2.407 times of those without(95% CI 2.012-2.880).Conclusions The high-risk age of HPV infection in Shanxi is 36-40 years old;the most common type of HPV infection is HPV16/58/52/53/51;the most pathogenic type is HPV16,58,31,33,52,whose distribution characteristics are different from those of other areas;short-term education,non-menopause,and non-menstrual use of pads are high-risk factors for HPV infection.更多还原