【摘要】 目的:探讨重症昏迷脑损伤患者经重复经颅磁刺激(rTMS)干预后脑电图(EEG)的前后变化,以期了解r TMS是否可以作为一种促醒治疗方法。方法:募集重症脑损伤患者10例,所有患者均处于昏迷状态(GCS<9),患者戴上TMS兼容电极帽,采用TMS兼容的EEG设备,在rTMS刺激前采集EEG20min;然后rTMS刺激左侧额叶背外侧区15min,刺激频率为15Hz,刺激强度80%运动阈值,未测出运动阈值者选择45%的最大输出强度;刺激结束后,继续采集EEG20min;观察rTMS刺激前后的EEG变化,分析Fp1、F3、C3、F7和T3总共5个通道的平均功率和慢波功率比在刺激前后间的差异。结果:相比于干预前,rTMS干预后的EEG波形分化会变好,平均功率呈下降趋势,其中在F3和C3通道上的差异具有显著性。5个通道的慢波比均显著降低。结论:rTMS刺激可以改善昏迷患者的EEG,也许可以作为脑损伤昏迷患者促醒的一种潜在治疗方法。更多还原

【Abstract】 Objective: To explore the local change of EEG in the severe brain injury patients after the intervention of repetitive transcranial magnetic stimulation(r TMS) and then investigating the possibility of r TMS to be an awaking up treatment.Method: Ten coma patients after severe brain injury(GSC<9) were recruited to attend this study. EEG was gathered using TMS compatible EEG system before and after r TMS intervention. The procedure is as followings,the stimulating site is left dorsolateral frontal lobe, the frequency was 15 Hz, the intensity was 80% motor threshold(if no motor threshold, 45% maximum intensity was chosen), the time of gathering EEG is no less than 20 min. The mean power and the rate of slow wave in Fp1、F3、C3、F7 and T3 channels were analyzed.Result: The EEG will be better after r TMS intervention. The mean power in five channels has decreasing trend and the difference in F3 and C3 is significant. The DTR in most channels is obviously decreased.Conclusion: r TMS can improve the EEG performance and may be a potential method to arouse awareness.更多还原