【摘要】 目的探究COPD患者的凝血纤溶指标有无异常及凝血纤溶指标随病史的变化。方法回顾性收集入组2017-01-01至2017-06-30间住院治疗的COPD急性加重期患者129例、缓解期76例、健康对照组132例。测定各组PT、APTT、FIB、D-D、PLT的水平及组间差异变化。结果急性加重期组PT、APTT、FIB、DD、PLT指标显著高于缓解期及对照组(P值均小于0.01),COPD缓解期各指标除PLT、APTT外均显著高于对照组(P均小于0.05)。不同COPD病史间患者PLT、FIB差异有统计学意义(P=0.001、P=0.001)。PLT、FIB与病史时间均呈正相关,PLT与病史相关性(r_s=0.543,P<0.001)优于FIB(r_s=0.18,P=0.0.1)。结论 COPD稳定期和急性加重期患者均处于高凝低纤溶状态,且PLT水平患者病史存在显著相关性。针对性的监测COPD患者凝血纤溶指标态,对COPD患者有一定的意义。更多还原

【Abstract】 Objective To explore the changes of blood coagulation and fibrinolysis index in patients with chronic obstructive pulmonary disease(COPD)and the index with the history of disease.Methods A retrospective study of 129 patients,from January 1,2017 to June 30,2017,with acute exacerbation of COPD,76 patients with stable of COPD and 132 cases in the healthy control group.Determination of plasma prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D)and platelet(PLT)and the level of difference between the two groups.Results PT,APTT,FIB,DD and PLT in acute exacerbation group were significantly higher than those in stable and control group(P<0.01),and all indexes in stable COPD except PLT and APTT were significantly higher than those in control group(P<0.05).There was a statistically significant difference in PLT and FIB between patients with differe.nt historys of COPD(P=0.001、P=0.001).PLT,FIB was positively correlated with the time of medical history,and PLT was correlated with medical history(r_s=0.543,P<0.001),which was better than FIB(r_s=0.18,P=0.01).Conclusion Stable and acute exacerbation of COPD patients were in hypercoagulable and hypofibrinolytic state,and PLT level was correlated with the length of history.Monitoring of coagulation and fibrinolysis index and PLT were significant for COPD patients.更多还原