【摘要】 目的探讨奥美拉唑联合内镜下止血夹治疗消化性溃疡并出血的疗效。方法选取2017年10月～2018年10月在我院消化内科治疗的消化性溃疡并出血患者98例,按治疗方法分为两组,观察组和对照组各49例,对照组单用静脉推注奥美拉唑进行治疗,观察组使用奥美拉唑联合内镜下止血夹治疗,比较两组患者的临床疗效、止血及再出血情况、胃液pH值变化、不良反应。结果观察组治疗总有效率为95.92%,明显高于对照组的77.55%,差异有统计学意义(P<0.05);观察组止血时间、住院时间明显短于对照组,且再出血率明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后12 h、24 h的空腹胃液pH值明显高于对照组,差异有统计学意义(P<0.05);观察组腹痛、恶心、皮疹等不良反应发生率与对照组相比无明显差异(P>0.05)。结论消化性溃疡并出血经奥美拉唑联合内镜下止血夹治疗后获得了较为满意的疗效,止血迅速彻底,能有效促进受损黏膜的修复,降低再出血率,缩短治疗时间,且不良反应发生率低,具有积极的临床意义。更多还原

【Abstract】 Objective To explore the efficacy of omeprazole combined with endoscopic hemostatic clip for peptic ulcer and bleeding. Methods 98 patients with peptic ulcer and hemorrhage treated in our hospital from October 2017 to October 2018 were selected and divided into two groups according to the treatment method, the observation group and the control group, 49 cases in each group. The control group was treated with intravenous injection of omeprazole. The observation group was treated with omeprazole combined with endoscopic hemostatic clip. The clinical efficacy, hemostasis and rebleeding, pH change of gastric juice and adverse reactions were compared between the two groups. Results The total effective rate of observation group was 95.92%, which was significantly higher than that of the control group(77.55%, P <0.05). The time of hemostasis and hospitalization in the observation group was significantly shorter than that of the control group, and the rebleeding rate was significantly lower than that of the control group(P<0.05). The pH value of fasting gastric juice in the observation group was significantly higher than that in the control group at 12 h and24 h after treatment(P<0.05). The incidence of adverse reactions such as abdominal pain, nausea and rash in the obser vation group was not significantly different from that in the control group(P>0.05). Conclusion Omeprazole combined with endoscopic hemostatic clip for the treatment of peptic ulcer and bleeding can obtain satisfactory results, with rapid and complete hemostasis, which can effectively promote the repair of damaged mucosa, reduce the rate of rebleeding,shorten the treatment time, with low incidence of adverse reactions, thus it has positive clinical significance.更多还原