【摘要】 骨代谢动态平衡是维持正常骨组织功能的重要因素之一,当平衡被打破,即造成骨损伤甚至骨代谢疾病。但目前骨代谢的机制尚不完全明确,影响骨代谢的信号通路复杂,疾病的治疗也尚在研究中。中医药对骨代谢的影响得到了越来越多的关注,探索中药影响骨代谢的机制成为治疗骨代谢疾病研究的新方向。目前在骨代谢中常见的机制有OPG/RANKL/RANK信号通路、Wnt/β-catenin信号通路、TGF-β/BMP/Smad信号通路及NF-κB信号通路等,综述中药对以上几种通路作用的研究进展,为进一步探索中药治疗骨代谢疾病提供参考。更多还原

【Abstract】 Dynamic balance of bone metabolism is one of the important factors to maintain normal osseous tissue function. When the balance is broken, it causes bone damage and even bone metabolic disease. However, the mechanism of bone metabolism is still unclear, the signal pathway is complex, and the treatment of diseases is still under study. The research on the mechanism of bone metabolism by Chinese materia medica has become a new direction in the treatment of bone metabolism diseases. At present, common mechanisms in bone metabolism include OPG/RANKL/RANK signal pathway, Wnt/β-catenin signal pathway, TGF-β/BMP/Smad signal pathway, and NF-κB signal pathway. In this paper, the research on the above pathways was reviewed, so as to provide a reference for further exploring the treatment of bone metabolism diseases with Chinese materia medica.更多还原