【摘要】 目的对南通市肿瘤医院2002-2014年以医院为基础的宫颈癌登记病例作生存率分析,为宫颈癌防治提供依据。方法采用主动随访与被动随访相结合的方法,对建立的以医院为基础的癌症登记数据库中来自启东、海门籍的宫颈癌住院患者开展生存结局的随访,随访截至2016年3月31日。用寿命表法计算各年观察生存率,并采用SPSS21软件作生存率比较分析,并用Gehan统计量评估差异的显著性。结果在南通市肿瘤医院住院的启东、海门籍宫颈癌患者为452例,随访获得癌症生存结局信息的为432例,随访率为95. 58%;失访20例,失访率为4. 42%。首次入院平均年龄为(51. 59±7. 07)岁。在各年龄组中40～59岁共计276例,占63. 89%。患者的1、3、5及10年总观察生存率分别为88. 43%、72. 74%、66. 58%及58. 01%。<40岁组、40～49岁组、50～59岁组、60～69岁组及≥70岁组的5年总观察生存率分别为68. 17%、75. 77%、68. 57%、54. 52%及43. 42%;<40岁组与60～69岁组生存率比较(Gehan=6. 144,P=0. 013)、40～49岁组与60～69岁组生存率比较(Gehan=4. 624,P=0. 032),差异均有统计学意义(P <0. 05)。启东籍宫颈癌患者1年、3年观察生存率略高于海门籍患者,而5年及10年观察生存率则低于海门籍患者,但差异无统计学意义(P> 0. 05)。结论本组以医院为基础的宫颈癌登记患者地区间差异不大,但各年龄组生存率比较差异有统计学意义。较高的患者随访率,完整体现了启海籍宫颈癌患者治疗的综合效果。更多还原

【Abstract】 Objective To analyze survival rates of registered cases of cervical cancer based on hospital in Nantong Cancer Hospital from 2002 to 2014 in order to provide basis for the evaluation of prognosis of cervical cancer. Methods Active follow-up and passive follow-up methods were used to obtain the information on the survival outcomes of hospitalized patients with cervical cancer from Qidong and Haimen in a hospital-based cancer registry. Follow-up ended on 31 March 2016. Survival probability was estimated using the lifetable method,and comparison was made by Gehan statistics. Results The outcomes of 432 patients were identified in the follow-up of452 cases from Qidong and Haimen,with a follow-up rate of 95. 58%,and a loss rate of 4. 42%(20 cases). The average age of the first-hospitalization was(51. 59 ± 7. 07) years old. The most commonly affected ages were 40-59 years old,accounting for 63. 89%.The 1-,3-,5-,and 10-year observed survival(OS) rate of cervical cancer were 88. 43%,72. 74%,66. 58% and 58. 01%,respectively. The 5-year OS rates of cervical cancer at age groups of 0-39,40-49,50-59,60-69,70+years were 68. 17%,75. 77%,68. 57%,54. 52% and 43. 42%,respectively. There were significant differences in overall OS rates at two age groups: 0-39 and 60-69 years old(Gehan = 6. 144,P = 0. 013); 40-49 and 60-69 years old(Gehan = 4. 624,P = 0. 032). Patients from Qidong seem to have experienced better survival than those patients from Haimen for the 1-,3-year OS rates,while the 5-,10-year OS rates seem little higher in patients from Haimen,but no significant differences were found(P > 0. 05). Conclusion There were no significant differences in overall OS rates between patients with cervical cancer from Qidong city and Haimen city,but the singnificant differences exist among age groups. Due to the high follow-up rate of patients,this study fully reflects the comprehensive effect of the treatment of Qidong-Haimen patients with cervical cancer patients at our hospital.更多还原