【摘要】 目的:探讨伤科黄水对SD大鼠连续灌胃给药的安全性。方法:将SD大鼠按体质量和性别随机均衡分为空白对照组(0.9%氯化钠溶液)、低剂量组(伤科黄水4.58 g/kg)、中剂量组(伤科黄水9.16 g/kg)和高剂量组(伤科黄水18.33 g/kg),每组8只,雌雄各半。四组大鼠均以10 ml/kg灌胃给药,1日1次,连续给药14 d。剖检当日处死全部大鼠,进行血液学、凝血功能、血清生化学及骨髓等各项检查。结果:与空白对照组相比,低剂量组、中剂量组和高剂量组大鼠的红细胞、白细胞、血小板体系和凝血功能等相关指标水平以及血液生化指标、骨髓检查结果,随着伤科黄水给药剂量的增加未见明显变化。结论:伤科黄水重复多次口服给药无明显的毒副作用。更多还原

【Abstract】 OBJECTIVE: To investigate the safety of Shangke Huangshui of intragastrical administration in SD rats. METHODS: SD rats were randomly divided into blank control group(0.9% sodium chloride solution), low dose group(Shangke Huangshui 4.58 g/kg), medium dose group(Shangke Huangshui 9.16 g/kg) and high dose group(Shangke Huangshui 18.33 g/kg) according to body mass and gender, with 8 rats in each group(half male and female). Four groups of rats were intragastrically administered at 10 ml/kg, once a day for 14 d. The index of hematology, blood clotting function, blood biochemistry and marrow of rats were examined after autopsy. RESULTS: Compared with the blank control group, there was no significant change in the related indexes such as red blood cell, leukocyte, platelet system, coagulation function, blood biochemical indexes and marrow examination results in the low dose, medium dose and high dose group with the increase of administration dose of Shangke Huangshui. CONCLUSIONS: Repeated oral administration of Shangke Huangshui has no obvious side effects.更多还原