【摘要】 目的探究经皮穿刺椎体成形术(PVP)对老年骨质疏松性胸腰椎骨折患者的治疗效果及对骨密度、骨钙素的影响。方法选择2017年3月～2018年4月在浙江省丽水市人民医院接受治疗的老年骨质疏松性胸腰椎骨折患者82例,按随机数字表法分为观察组43例和对照组39例。对照组进行保守治疗,观察组进行PVP治疗,比较两组临床疗效、椎体压缩率、Cobb角、骨密度、骨钙素水平以及日常活动能力评分。结果观察组总有效率明显高于对照组(P <0.05);观察组椎体压缩率、Cobb角治疗1周后明显低于治疗前,且低于对照组(P <0.05);对照组椎体压缩率明显低于治疗前(P <0.05),而Cobb角与治疗前比较,差异无统计学意义(P> 0.05);两组患者骨密度、骨钙素水平均明显高于治疗前(P <0.05),且观察组的骨密度、骨钙素水平明显高于对照组(P <0.05);观察组患者治疗后的日常活动能力评分明显低于治疗前和对照组(P <0.05)。结论 PVP对老年骨质疏松性胸腰椎骨折患者具有较好的临床疗效,能显著改善患者的椎体愈合情况,提高骨密度、骨钙素以及日常活动能力。更多还原

【Abstract】 Objective To explore the therapeutic effect of percutaneous vertebroplasty(PVP) on elderly patients with osteoporotic thoracolumbar fracture and its effect on bone mineral density and osteocalcin. Methods A total of 82 elderly patients with osteoporotic thoracolumbar fractures who were treated in Lishui People′s Hospital from March 2017 to April 2018 were selected and divided into the observation group(43 cases) and the control group(39 cases) according to the random number table. The control group received conservative treatment, while the observation group received PVP treatment, the clinical efficacy, vertebral compression rate, Cobb angle, bone mineral density, osteocalcin level and daily activity ability of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). Vertebral compression rate and Cobb angle in the observation group were significantly lower than those before treatment and in the control group(P < 0.05). The vertebral compression rate in the control group was significantly lower than that before treatment(P < 0.05), but the Cobb angle had no significant difference(P > 0.05). The bone mineral density and osteocalcin levels in the two groups were significantly higher than those before treatment(P < 0.05), and the bone mineral density and osteocalcin levels in the observation group were significantly higher than those in the control group(P < 0.05). The daily activity ability of the patients in the observation group was better than that in the control group and before treatment(P < 0.05). Conclusion PVP has a good clinical effect on elderly patients with osteoporotic thoracolumbar fracture, it can significantly improve the healing of vertebral body, promote vertebral fusion, improve bone mineral density, osteocalcin and daily activity ability.更多还原