【摘要】 目的探讨双歧杆菌四联活菌片联合早期肠内营养治疗重型颅脑损伤的效果。方法选取2016年1月～2018年5月辽宁省本溪市中心医院收治的重型颅脑损伤患者102例。根据随机数字表法将患者随机分为对照组(51例)和研究组(51例),对照组给予早期肠内营养治疗,研究组在对照组的基础上联合双歧杆菌四联活菌片治疗。比较两组治疗前后营养状态、体液免疫、炎性因子水平情况,记录两组患者治疗期间并发症发生情况。结果两组患者治疗后白蛋白、转铁蛋白、前白蛋白、血红蛋白均较治疗前明显升高,且研究组高于对照组(P <0.05)。两组患者治疗后免疫球蛋白A、免疫球蛋白G、免疫球蛋白M均较治疗前明显升高,且研究组高于对照组(P <0.05)。两组患者治疗后炎性因子白介素-6、C反应蛋白、肿瘤坏死因子-α以及白细胞计数均较治疗前明显降低,且研究组低于对照组(P <0.05)。研究组治疗期间并发症发生率显著低于对照组(P <0.05)。结论双歧杆菌四联活菌片联合早期肠内营养治疗重型颅脑损伤可有效改善患者营养状态,提高机体免疫,减轻患者炎性反应,同时还可降低并发症发生率,具有一定的临床应用价值。更多还原

【Abstract】 Objective To investigate the effect of Bifidobacterium Tetravaccine Tablets combined with early enteral nutrition on severe craniocerebral injury. Methods A total of 102 patients with severe craniocerebral injury who were treated in Benxi Central Hospital of Liaoning Province from January 2016 to May 2018 were selected. The patients were randomly divided into control group(51 cases) and study group(51 cases) according to the random number table method. The control group was given early enteral nutrition treatment. The study group was treated with Bifidobacterium Tetravaccine Tablets on the basis of the control group. The nutritional status, humoral immunity and inflammatory factors of the two groups were compared before and after treatment, the complications in the two groups during treatment were recorded. Results After treatment, the levels of albumin, albumin, prealbumin and hemoglobin in the two groups were higher than those before treatment, which of the study group were higher than those of the control group(P <0.05). After treatment, the levels of immune globulin A, immune globulin G and immune globulin M in the two groups were all higher than those before treatment, which of the study group were higher than those of the control group(P <0.05). After treatment, the levels of inflammatory factors interleukin-6, C-reactive protein, tumor necrosis factor-α and white blood cell counts in the two groups were all lower than those before treatment, which of the study group were lower than those of the control group(P < 0.05). The incidence of complications during treatment in the study group was significantly lower than that in the control group(P < 0.05). Conclusion Bifidobacterium Tetravaccine Tablets combined with early enteral nutrition in the treament of severe craniocerebral injury can effectively improve the nutritional status of patients, enhance immunity, alleviate inflammatory reactions, and reduce the incidence of complications, which has a certain clinical value.更多还原