【摘要】 目的探讨PSCA基因多态性位点与胃溃疡的遗传学关联。方法采用候选基因的遗传学关联研究策略,基于来自中国汉族人群的688名胃溃疡患者以及1 442名健康对照受试者,对覆盖PSCA基因的11个SNP位点与胃溃疡的潜在关联进行考察。利用c2检验来对单个SNP位点的关联信号进行统计分析。结果SNP位点rs2294008与胃溃疡的疾病状态存在显著性关联(OR=0.73,P=4.78×10-5),该SNP的T等位基因在对照组中的分布频率高于病例组差异有统计学意义(P<0.05),因而具有一定的保护性作用。结论 PSCA基因可能是胃溃疡的易感基因。更多还原

【Abstract】 [ABSTACT] Objective To explore the genetic relationship between PSCA gene polymorphism and gastric ulcer. Methods A total of 688 gastric ulcer patients and 1442 healthy control subjects from Chinese Han population were recruited. The potential association between gastric ulcer and 11 SNP loci covering PSCA gene was investigated by using the genetic association strategy of candidate genes. c2 test was used to analyze the correlation signals of single SNP locus. Results The results indicated that there was a significant correlation between the SNP locus rs2294008 and the disease status of gastric ulcer(OR=0.73,P=4.78×10-5).The distribution frequency of the SNP T allele in the control group was significantly higher than that in the case group(P<0.05). Therefore,it has a certain protective effect. Conclusion PSCA gene may be the susceptible gene of gastric ulcer.更多还原