【摘要】 目的通过对血清低病毒载量HBV DNA(<1 000 IU/mL)乙型肝炎相关性肝细胞肝癌(HCC)患者检测,探讨乙型肝炎病毒血清高灵敏度HBV DNA检测水平对乙型肝炎相关性肝细胞肝癌临床治疗的帮助。方法选取2016年2月至2018年10月在江汉大学附属湖北省第三人民医院门诊和住院的,普通荧光探针法HBV DNA水平持续小于1 000 IU/mL的96例HCC患者血清,进行血清高灵敏度HBV DNA检测,分析患者血清免疫学标志、肝功能指标与HBV DNA水平的相关性和临床意义。结果 96例乙型肝炎相关性HCC患者当中,HBV DNA水平大于10 IU/mL有74例(77.1%)。HBV DNA水平大于10 IU/mL者的肝硬化发生率、肝功能指标(ALT、γ-GT)异常率均较HBV DNA水平小于10 IU/mL者高。结论乙型肝炎相关性HCC与乙型肝炎病毒持续复制有关,高灵敏度HBV DNA检测较普通荧光探针法HBV DNA检测更有临床指导意义。更多还原

【Abstract】 Objective To investigate the relationship between hepatitis B virus serum high-sensitivity HBV DNA detection and hepatocellular carcinoma(HCC)by detecting low-viral HBV DNA(<1 000 IU/mL)in patients with hepatitis B-associated hepatocellular carcinoma(HCC). Methods From February 2016 to October 2018,96 patients with HCC who had HBV DNA levels of less than 1 000 IU/mL in the general outpatient and inpatient hospitals of the Third People s Hospital of Hubei Province affiliated to Jianghan University were selected. Serum high-sensitivity HBV DNA was detected to analyze the correlation and clinical significance of serum immunological markers,liver function markers and HBV DNA levels.Results Of the 96 patients with hepatitis B-related HCC,74(77.1%)had HBV DNA levels greater than 10 IU/mL. The incidence of cirrhosis and liver function(ALT,γ-GT)in patients with HBV DNA levels greater than 10 IU/mL were higher than those with HBV DNA levels less than 10 IU/mL. Conclusion HBVrelated HCC is associated with the continuous replication of hepatitis B virus. High-sensitive HBV DNA detection is more clinically significance than HBV DNA detection by common fluorescent probe methods.更多还原