【摘要】 目的探讨酒精所致精神病性障碍药物干预的疗性及安全性。方法选择2018年2月～2019年1月在我院住院的符合ICD-10诊断标准中酒精所致精神性障碍的患者105例,随机分为帕利哌酮组、喹硫平组及对照组,各35例。三组患者入组后均停饮白酒,予奥沙西泮治疗1周,之后帕利哌酮组给予帕利哌酮,喹硫平组采用喹硫平治疗,对照组不服药。入组前及入组后2、4、8周采用阳性和阴性症状量表(PANSS)评定患者症状改善情况,采用副反应量表(TESS)评定药物不良反应。结果共99例患者完成随访评估,其中帕利哌酮组完成34例,喹硫平组完成32例,对照组完成33例;入组第2周时,三组PANSS评分比较,差异无统计学意义(P>0.05);第4周时,对照组评分高于帕利哌酮组和喹硫平组,差异有统计学意义(P<0.05);第8周三组PANSS评分比较,差异无统计学意义(P>0.05);治疗期间,三组不良反应发生率比较,差异无统计学意义(P>0.05)。结论酒精所致精神病性障碍治疗,虽然给予抗精神病药与单纯戒断酒精最终结局可能一致,但服用抗精神病药可加快患者症状改善,且不增加不良反应。更多还原

【Abstract】 Objective To investigate the therapeutic and safety of drug interventions for psychotic disorders caused by alcohol.Methods 105 patients with mental disorders caused by alcohol in the ICD-10 diagnostic criteria were enrolled in our hospital from February 2018 to January 2019. They were randomly divided into paliperidone group, quetiapine group and control group. 35 cases each. Three groups of patients were stopped drinking white wine and treated with oxazepam for 1 week. After the paliperidone group was given paliperidone, the quetiapine group was treated with quetiapine, and the control group was not taken. Positive and negative symptom scales(PANSS) were used to assess the improvement of symptoms before and 2, 4, and 8 weeks after enrollment. The side effects scale(TESS) was used to assess adverse drug reactions. Results A total of 99 patients completed the follow-up evaluation, including 34 patients in the paliperidone group, 32 patients in the quetiapine group, and 33 patients in the control group. At the second week of enrollment, there was no significant difference in the PANSS scores of the three groups.( P>0.05); at the 4 th week,the control group score was higher than the paliperidone group and the quetiapine group, the difference was statistically significant( P<0.05); the 8 th week group 3 PANSS scores were compared, the difference was not statistically significant( P >0.05); during the treatment period, the incidence of adverse reactions in the three groups was not statistically significant(P>0.05).Conclusion The treatment of psychotic disorders caused by alcohol may be consistent with the final outcome of anti-psychotic drugs and simple withdrawal alcohol, but taking antipsychotic drugs can speed up the improvement of patients’ symptoms without increasing adverse reactions.更多还原