【摘要】 目的:以羊腰椎体骨煅烧后的灰重密度为标准,比较能谱CT与双能X线骨密度仪(DXA)测量椎体骨密度(BMD)的准确性,探讨能谱CT对BMD的测量价值。方法:选取36节新鲜市售羊腰椎椎体作为研究对象,清除椎体周围软组织及其附件后,分别采用能谱CT与DXA测量BMD,然后煅烧椎体得到灰重密度。将两种方法测量所得BMD值与灰重密度值进行比较,同时分析两种方法测量所得BMD值与灰重密度值的相关性;最后将能谱CT测得BMD的偏离度与DXA测得体积BMD的偏离度进行比较。结果:能谱CT、DXA测得BMD值与灰重密度值差异有统计学意义(P<0.05);相关性分析可得,能谱CT与DXA测得BMD值与灰重密度值均有显著相关性(P<0.05),但能谱CT相关性更高;能谱CT测得BMD的偏离度(平均值为0.288)低于DXA测得BMD的偏离度(平均值为0.372)(P<0.05)。结论:能谱CT测量椎体BMD值更接近灰重密度值,准确性及相关性均优于DXA测量方法,能够更好、更精确地反映BMD变化。更多还原

【Abstract】 Objective With the ash density of sheep lumbar vertebrae as the standard, to compare the accuracy of spectral computed tomography(CT) and dual-energy X-ray absorptiometry(DXA) for vertebral bone mineral density(BMD)measurement, and to investigate the value of spectral CT in BMD measurement. Methods A total of 36 freshly prepared sheep lumbar vertebrae were selected as the research object. After removing soft tissue around the vertebral body and its attachments, BMD was measured by spectral CT and DXA, and the vertebral body was calcined to obtain the ash density.The BMD values measured by the two methods were compared with ash density, and the correlations between the measured BMD values and ash density were analyzed. Finally, the deviation of BMD measured by energy spectrum CT was compared with the deviation of BMD measured by DXA. Results The difference between measured BMD and ash density was statistically significant(P<0.05). There was a significant correlation between measured BMD and ash density(P<0.05), but the correlation of ash density and BMD measured with spectral CT was higher. The mean deviation of BMD measured by spectral CT was lower than the mean deviation of BMD measured by DXA(0.288 vs 0.372, P<0.05). Conclusion The BMD measured by spectral CT is closer to ash density. Spectral CT is superior to DXA in BMD measurement accuracy and the correction with ash density, which indicates that spectral CT can reflect the changes of BMD more accurately.更多还原