【摘要】 目的:观察胰激肽原酶肠溶片佐治糖尿病性慢性假性肠梗阻的临床疗效。方法:选取40例糖尿病性慢性假性肠梗阻患者,随机分为对照组和观察组,20例对照组给予调控血糖、调整饮食、抑制胃酸分泌、灌肠通便、调节肠道动力等对症治疗;20例观察组在对照组治疗的基础上加用胰激肽原酶肠溶片240U tid,疗程均为4周。分析两组患者用药前后慢性假性肠梗阻症状的改善情况。结果:(1)观察组和对照组治疗4周后假性肠梗阻治疗总有效率分别为85.00%和55.00%,观察组明显高于对照组(P=0.023);(2)用药后两组总症状积分分别低于用药前[对照组:(4.20±1.64) VS (8.20±1.48),P=0.003;观察组:(1.80±1.30) VS (7.40±0.55),P=0.001];并且用药后观察组总症状积分较对照组更低[(1.80±1.30)VS (4.20±1.64),P=0.034]。结论:胰激肽原酶能有效改善糖尿病性慢性假性肠梗阻的消化道症状。更多还原

【Abstract】 Objective:To investigate therapeutic effects of pancreatic kininogenase enteric-coated tablets on treating diabetic chronic intestinal pseudo-obstruction(CIPO).Methods:Forty patients with diabetic chronic intestinal pseudo-obdtrction were randomly divided into observation group and control group.20 patients in control group were given with insulin regulation of blood glucose, diet modification, gastric acid suppression,purge enema, regulation of intestinal motility and other symptomatic treatment were provided.20 patients in the observation group were provided with pancreatic kininogenase enteric-coated tablets(240 unit,3 times daily with fasting status) for 4 weeks on the basis of administration in congtrol group. Changes of clinical smptoms and side effects were evaluated.Results:The total effective rates for symptoms in control group and observation group after therapy were 55.00% and 85.00% respectively, there were obvious difference statistically(P=0.023<0.05).The total symptom scores in two groups after administration were lower than that of former[control group:(4.20±1.64) VS(8.20±1.48), P=0.003<0.01;observation group:(1.80±1.30) VS(7.40±0.55),P=0.001<0.01].The total symptoms scores of CIPO after administration had obvious difference between observation group and control group[(1.80±1.30) VS(4.20±1.64), P= 0.034<0.05].Conclusion:Pancreatic kininogenase may be used to treat effectively CIPO patients.更多还原