【摘要】 目的研究注射用丹参多酚酸对短暂性脑缺血发作的临床疗效。方法将大庆市中医医院2017年1月—2018年8月收治的短暂性脑缺血发作患者80例,随机分成观察组与对照组,各40例。对照组采取口服盐酸氟桂利嗪联合阿司匹林的常规治疗,观察组在常规治疗基础上加用注射用丹参多酚酸0.13 g用0.9%氯化钠注射液250 mL稀释,静脉滴注1次/d。两组疗程均为14 d,观察临床疗效。采用经颅多普勒超声仪对两组患者在治疗前后大脑前动脉(ACA)、大脑中动脉(MCA)及大脑后动脉(PCA)脑血管的血流速度进行检测。结果观察组治疗总有效率为92.5%,对照组的总有效率为70.0%,两组比较差异具有统计学意义(P<0.05)。治疗后两组的ACA、MCA、PCA峰值流速均较治疗前明显改善,且观察组的改善程度优于对照组的(P<0.05)。结论丹参多酚酸能改善脑部血流动力学,有效改善脑缺血症状,对短暂性脑缺血发作有良好的疗效。更多还原

【Abstract】 Objective To explore the clinical effect of Salvianolic Acids for Injection(SAFI) on transient ischemic attack. Methods A total of 80 patients with transient ischemic attack in Daqing Traditional Chinese Medicine Hospital from January 2017 to August2018, were randomly divided into treatment group and control group, 40 cases in each group. The control group was treated with flunarizine hydrochloride combined with aspirin. The treatment group was given 0.13 g SAFI dissolved in 0.9% sodium chloride injection 250 mL by intravenous drip once a day based on the treatment of the control group. The course of treatment was 14 d in two groups, and the therapeutic effects of two groups were compared. Transcranial Doppler ultrasonography(TCD) was used to detect the cerebral blood flow velocity before and after treatment in two groups. TCD was used to determine the three main cerebrovascular response to cerebral blood flow: anterior cerebral artery(ACA), middle cerebral artery(MCA) and posterior cerebral artery(PCA). Results The total effective rate was 92.5% in the treatment group and 70.0% in the control group. The difference between the two groups was statistically significant(P < 0.05). After treatment, the improvement of peak velocity of ACA, MCA and PCA in two groups were better than those before treatment(P < 0.05), and treatment group was better than that in control group(P < 0.05).Conclusion SAFI can improve cerebral hemodynamics and cerebral ischemic symptoms, and has a good therapeutic effect on transient ischemic attack.更多还原