【摘要】 目的探讨间歇性肺康复训练对特发性肺纤维化(IPF)患者心肺功能及生活质量的改善效果。方法 70例IPF患者纳入了本次研究,按随机数字表法分为观察组与对照组各35例,观察组进行为期12周的间歇性肺康复训练。测量基线与训练后肺功能指标、心肺运动试验(CPET)、6 min步行距离(6MWD)、呼吸困难与健康相关的生活质量。结果观察组训练后用力肺活量(FVC)%、pred第1秒用力呼气容积占预计值百分比(FEV1)%pred、最大通气自主量(MVV)及静息脉搏氧饱和度(SpO2)较基线上升值高于对照组(P<0.05)。观察组WR(work rate)、6MWD、VO2峰值及无氧阈值的上升均高于对照组。观察组在生活质量改善及呼吸困难的缓解程度优于对照组(P<0.05)。结论间歇性康复训练可有效改善患者呼吸困难与心肺功能,提高患者生活质量。更多还原

【Abstract】 Objective To determine the impact of intermittent pulmonary rehabilitation on cardiopulmonary function and quality of life in patients with idiopathic pulmonary fibrosis(IPF). Methods Seventy IPF patients were included and randomly divided into the study group and control group(n=35 each). The study group underwent 12-week intermittent pulmonary rehabilitation. Baseline and post-training lung function parameters, cardiopulmonary exercise test(CPET), 6-minute walk distance(6 MWD), dyspnea and health-related quality of life were measured. Results After the training, the increases in FVC%, pred FEV1%, MVV and resting SpO2 from the baseline in the study group were greater than those in the control group(P<0.05). The increases of work rate(WR), 6 MWD, peak VO2 and anaerobic threshold in the study group were also greater higher than those in the control group. The improvement in quality of life and dyspnea in the study group was more significant compared with the control group(P<0.05). Conclusion Intermittent rehabilitation may effectively improve dyspnea, cardiopulmonary function and quality of life in IPF patients.更多还原