【摘要】 目的观察丹参多酚酸盐治疗肝硬化的临床效果。方法选择我院收治的120例肝硬化患者为研究对象,根据肝硬化病程进展分为代偿期组(52例)及失代偿期组(68例),各组按随机数字法又分为治疗组及对照组,分别为代偿期对照组(24例)和治疗组(28例),失代偿期对照组(32例)和治疗组(36例)。对照组均给予常规保肝治疗措施,治疗组在对照组基础上加用丹参多酚酸盐,两组均治疗14 d。比较四组治疗效果。结果治疗后,代偿期、失代偿期各组肝功能指标(TBiL、ALT、AST、CHE)水平、肝纤维指标(CⅣ、LN、HA)、凝血功能指标(PT、APTT、TT)均改善,且同期治疗组均明显优于对照组(P<0.05)。治疗后,失代偿期治疗组上述指标水平改善程度显著优于代偿期治疗组,差异具有统计学意义(P<0.05)。结论丹参多酚酸盐可改善肝硬化患者肝功能、肝纤维及凝血功能指标,且其对失代偿期患者的改善程度优于代偿期患者。更多还原

【Abstract】 Objective To observe the clinical effect of salvianolate in the treatment of liver cirrhosis. Methods A total of 120 patients with liver cirrhosis admitted in our hospital were selected as the research objects. According to the progress of cirrhosis, patients were divided into compensatory period group(52 cases) and decompensated period group(68 cases).Each group was divided into treatment group and control group according to random number method, including compensatory period control group(24 cases) and treatment group(28 cases), decompensated period control group(32 cases) and treatment group(36 cases). The control group was treated with routine hepatoprotective, while the treatment group was treated with salvianolate on the basis of the control group, all groups were treated for 14 days. The therapentic effects of the four groups were compared. Results After treatment, the levels of liver function indexes(TBiL, ALT, AST,CHE), liver fibre indexes(CⅣ, LN, HA), and blood coagulation function indexes(PT, APTT, TT) in the compensatory and decompensated period groups all improved, and those in the same period treatment group were significantly better than the compensatory and decompensated period control group(P <0.05). After treatment, the levels of the above indexes in the decompensated period treatment group was significantly better than those in the compensated period treatment group, and the differences were statistically significant(P <0.05). Conclusion Salvianolate can improvethe levels of liver function indexes, liver fibre indexes and blood coagulation function indexes in patients with cirrhosis, and the degree of improvement in decompensated period is better than that in the compensatory period.更多还原