【摘要】 目的研究腔镜微创手术对结肠癌患者免疫功能及胃肠道功能的影响。方法将我院收治的160例结肠癌患者,根据选择手术方式的不同将其分为对照组和观察组,每组80例。对照组行开腹手术治疗,观察组行腔镜微创手术治疗。比较两组患者的治疗效果。结果手术前,两组患者的血清CA199、CEA、CA153及CA125阳性率比较,差异不显著(P>0.05);手术后,观察组的血清CA199、CEA、CA153及CA125阳性率均低于对照组(P<0.05);手术前,两组患者CD4~+、CD8~+、CD4~+/CD8~+以及NK细胞水平比较,差异不显著(P>0.05);手术后,观察组CD4~+、CD4~+/CD8~+以及NK细胞水平均高于对照组(P<0.05);观察组术后肠鸣音恢复、排气、进流食以及排便时间均短于对照组(P<0.05);观察组手术后0、4、8、12 h的VAS评分低于对照组(P<0.05),两组患者术后24 h的VAS疼痛评分比较,差异不显著(P>0.05)。结论腔镜微创手术治疗结肠癌的效果显著,可缓解患者的疼痛,还可改善患者的免疫功能,并能显著提高患者的胃肠道恢复效率。更多还原

【Abstract】 Objective To investigate the effect of laparoscopic minimally invasive surgery on immune function and gastrointestinal function in patients with colon cancer. Methods A total of 160 patients with colon cancer in our hospital were divided into control group and observation group according to the differenct choice of operation methods, with 80 cases in each group.The control group undergoing laparotomy surgery, while the different observation group undergoing laparoscopic minimally invasive surgery.The therapeutic effects of the two groups were compared. Results Before operation, there were no significant differences in positive rates of serum CA199, CEA, CA153 and CA125 between the two groups(P >0.05).After operation, the positive rates of serum CA199, CEA, CA153 and CA125 in the observation group were lower than those in the control group(P<0.05). Before operation, there were no significant differences in the levels of CD4~+, CD8~+, CD4~+/CD8~+and NK cell between the two groups(P >0.05). After operation, the levels of CD4~+,CD4~+/CD8~+and NK cell in the observation group were higher than those in the control group(P<0.05). The postoperative recovery time of bowel sounds, exhaust time, eating liquid diet time and defecation time of the observation group were shorter than those of the control group(P<0.05). The VAS scores at 0, 4, 8, 12 hours after operation in the observation group were lower than those in the control group(P<0.05), but there was no significant difference in VAS scores at 24 hours after operation between the two groups(P >0.05). Conclusion Laparoscopic minimally invasive surgery for colon cancer patients has a significant effect, which can relieve the pain, improve the immune function of patients and significantly improve the recovery efficiency of patients’ gastrointestinal tract.更多还原