【摘要】 目的分析孕中期孕妇铁营养状况与甲状腺功能的相关性。方法常规产检的孕中期孕妇442例分为三组:铁缺乏（ID）组142例,血清铁蛋白<15μg/L,Hb>110g/L;缺铁性贫血（IDA）组148例,血清铁蛋白<15μg/L,Hb<110g/L;正常对照（C）组152例,血清铁蛋白≥15μg/L,Hb≥110g/L。检测并比较三组TSH、FT₃、FT₄、甲状腺过氧化物酶抗体（TPOAb）和尿碘水平。结果 C组、ID组和IDA组尿碘中位数分别为200、150和150μg/L,差异无统计学意义（P>0.05）。IDA组血清FT₃和FT4水平低于ID组和C组[（4.13±0.37）pmol/L vs.（4.20±0.51）pmol/L和（4.49±0.46）pmol/L和（13.64±1.78）pmol/L vs.（13.90±1.70）pmol/L和（15.33±1.85）pmol/L]（P<0.05）,且ID组血清FT₃及FT₄水平亦低于C组（P<0.05）。Pearson相关性分析显示,血清铁蛋白与FT₃和FT₄呈正相关（r=0.376和0.336,P<0.01）。结论孕中期孕妇营养性ID与甲状腺功能的改变密切相关。更多还原

【Abstract】 Objective To analyze the correlation of iron nutrition status and thyroid function in pregnant women of second trimester.Methods A total of 442 pregnant women in the second trimester was divided into three groups.The patients in group ID（142 cases）were with serum ferritin<15μg/L and Hb>110 g/L,those in group IDA（148 cases）were with serum ferritin<15μg/L and Hb<110 g/L and those in group C（152 cases）were with serum ferritin≥15μg/L and Hb≥110 g/L.Serum levels of thyroid stimulating hormone（TSH）,free triiodothyronine（FT₃）,free thyroxine（FT₄）and thyroid peroxidase antibody（TPOAb）as well as urinary iodine were detected and compared among three groups.Results The median urinary iodine in groups of C,ID and IDA were 200,150,150μg/L,respectively,which was not significantly different among three groups（P>0.05）.Serum FT₃ and FT₄ levels in group IDA were lower than those in groups of ID and C[（4.13±0.37）pmol/L vs.（4.20±0.51）pmol/L and（4.49±0.46）pmol/L and（13.64±1.78）pmol/L vs.（13.90±1.70）pmol/L and（15.33±1.85）pmol/L]（P<0.05）,which were lower in group ID than those in group C（P<0.05）.Pearson correlation analysis showed that serum ferritin was positively correlated with FT₃ and FT₄（r=0.376 and 0.336,P<0.01）.Conclusion The nutritional iron deficiency is closely related to thyroid function in pregnant women in the second trimester.更多还原