【摘要】 心血管疾病已成为我国重大的公共卫生问题,临床上亟需新的诊疗方法来提高心血管疾病的防治水平。外泌体是由不同细胞分泌的纳米级脂质膜囊泡,其通过输送囊泡内容物(蛋白质、核酸等)介导细胞间的通讯,广泛参与机体的病理生理过程。肾素-血管紧张素系统是人体内重要的体液调节系统,在心血管疾病的发生发展中具有重要作用。研究显示外泌体和肾素-血管紧张素系统存在交互作用,共同参与心血管疾病的病理过程。在本篇综述中,我们主要概述外泌体与肾素-血管紧张素系统的相互作用在心血管疾病中的研究现状。更多还原

【Abstract】 Cardiovascular diseases has become the most important public health issue in China,and new diagnostic and therapeutic methods are urgently needed to improve the level of prevention and treatment of cardiovascular diseases.Exosomes are membrane-derived nanovesicles secreted by different cells,which mediate cell-to-cell communication by transporting vesicle contents(proteins,nucleic acids,etc.) and widely participate in the pathophysiological process.Renin-angiotensin system(RAS) is an important humoral regulation system in human body and plays an important role in the occurrence and development of cardiovascular diseases.Studies have shown that exosomes interact with RAS,collectively participate in the pathological process of cardiovascular diseases.In this review,we summarize the research status of the interaction between exosomes and RAS in cardiovascular diseases.更多还原