【摘要】 [目的]探讨延边地区朝鲜族HLA-DR,DQ基因多态性与流行性出血热(EHF)的相关性.[方法]采用聚合酶链反应-序列特异性引物技术对118例EHF患者(患者组)和120例健康对照者(对照组)进行HLA-DR, DQ基因分型,比较等位基因频率(GF),并计算相对危险度(RR).[结果]患者组HLA-DRB1*15,DRB1*16等位基因频率分别为4.66%,31.40%,较对照组(1.25%,15.80%)明显增高,χ~2值为4.92,11.50,P值为0.03,0.00,RR为3.58,3.63.两组其他HLA-DRB基因频率间差异均无统计学意义(P>0. 05);两组各HLA-DQB1基因频率间差异亦无统计学意义(P>0. 05).[结论] HLA-DRB1*15,DRB1*16可能是延边地区朝鲜族EHF的易感基因.更多还原

【Abstract】 OBJECTIVE To explore the correlation between HLA-DR,DQ gene polymorphisms and epidemic hemorrhagic fever(EHF) among Korea nationality in Yanbian area. METHODS HLA-DR, DQ genotyping was performed in 118 EHF patients(patient group) and 120 healthy persons(control group) using polymerase chain reaction-sequence specific primer technique. Gene frequency(GF) was compared and relative risk(RR) was calculated. RESULTS The gene frequencies of HLA-DRB1*15 and DRB1*16 in the patient group(4.66%, 31.4%) were significantly higher than those in the control group(1.25%,15.80%). χ~2 values were 4.92 and 11.50, P values were 0. 03,0. 00, and RR were 3.58 and 3.63. There was no significant difference in the frequency of other HLA-DRB genes between the two groups(P>0. 05). There was no statistically significant difference in HLA-DQB1 gene frequency between the two groups(P>0. 05). CONCLUSION HLA-DRB1*15 and DRB1*16 might be the susceptibility genes of Korea Nationality EHF in Yanbian area.更多还原