【摘要】 目的研究窄带成像技术（NBI）结合放大内镜观察幽门螺杆菌（Hp）感染时胃黏膜微细结构变化的特点,进而探讨NBI结合放大内镜在判断Hp感染的可行性及优势。方法选择130例行NBI结合放大内镜检查患者作为研究对象,同时采取¹⁴C尿素呼气试验、快速尿素酶法、组织切片法检测Hp感染,对NBI结合放大内镜观察胃黏膜微细结构和血管图像的价值进行分析。结果金标准阳性患者,NBI结合放大内镜下胃黏膜集合小静脉表现为I型（93.7%）和D型（96.2%）的Hp感染率高于R型（6.3%）;金标准阴性患者,I型（8.6%）和D型（5.7%）感染率低于R型（91.4%）,P均<0.05;即I型和D型与金标准符合率较高。结论 NBI结合放大内镜可以作为辅助诊断Hp的一种方法,主要是表现为I型和D型者。更多还原

【Abstract】 Objective To study the characteristics of narrow-band imaging（NBI） combined with magnifying endoscopy to observe the changes of microstructure of gastric mucosa in patients with Helicobacter pylori（Hp） infection, and to explore the feasibility and advantages of NBI combined with magnifying endoscopy in the diagnosis of Hp infection. Methods A total of 130 patients undergoing NBI combined with magnifying endoscopy were enrolled in the study. The ¹⁴C urea breath test, rapid urease method and histological staining were performed to detect the Hp infection. The values of NBI combined with magnifying endoscopy in observing the fine structure of the gastric mucosa and blood vessels were analyzed. Results In patients with positive gold standard, NBI combined with magnifying endoscopic showed that Hp infection rates of type I（93.7%）and type D（96.2%） were higher than those of type R（6.3%）; in patients with negative gold standard, infection rates of type I（8.6%）and type D（5.7%） were lower than those of type R（91.4%）, all P <0.05. The conformity of type I and type D with gold standard was higher. Conclusions NBI combined with magnifying endoscopy can be utilized to diagnose Hp infection. The conformity of type I and type D with gold standard was higher.更多还原