【摘要】 目的探讨原发性胆汁性肝硬化(PBC)患者血小板4项参数[血小板计数(Plt)、血小板压积(PCT)、平均血小板容积(MPV)、血小板分布宽度(PDW)]的变化及其临床意义。方法收集2014年1月至2017年4月在该院住院的84例确诊为PBC患者(PBC组)的临床资料,收集同期该院67例健康体检者(对照组)临床资料。比较2组间血小板4项参数和生化指标的差异,评估血小板参数与生化指标、清蛋白-胆红素评分模型(ALBI)评分的相关性。结果与对照组比较,PBC组患者Plt、PCT、清蛋白(ALB)水平显著降低,而谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷氨酰转移酶(GGT)、球蛋白(GLB)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、总胆汁酸(TBA)水平显著升高,差异均有统计学意义(P<0.01),2组间MPV及PDW水平比较,差异均无统计学意义(P>0.05)。Spearman相关性分析显示,Plt与ALT、AST、ALP、GGT、ALB呈正相关[相关系数(r)=0.309、0.294、0.343、0.420、0.368,P<0.05或0.01];PCT与ALT、AST、ALP、GGT、ALB呈正相关(r=0.306、0.301、0.326、0.441、0.387,P<0.05或0.01);Plt、PCT均与ALBI评分呈负相关(r=-0.298、-0.312,P<0.01)。结论 Plt、PCT在PBC患者中显著降低,且与生化指标、ALBI评分有良好的相关性,可为PBC患者病情严重程度和预后的初步评估提供重要参考。更多还原

【Abstract】 Objective To investigate the changes of platelet 4 parameters(Plt,PCT,MPV,PDW)in patients with primary biliary cirrhosis(PBC)and their clinical significance.Methods Totally 84 cases of hospitalized patients diagnosed with PBC(PBC group)and 67 healthy subjects for routine medical check-up(control group)from January 2014 to April 2017 were selected in the study.The differences of platelet 4 parameters and biochemical indices between two groups were compared.The correlations between platelet parametersand biochemical indices,Albumin-bilirubin prognosis score model(ALBI)score of patients with PBC were analyzed.Results Compared with the control group,the Plt,PCT and ALB in PBC group were significantly decreased,while ALT,AST,ALP,GGT,GLB,TBIL,DBIL,IBIL and TBA in PBC group were evidently higher,the differences were statistically significant(P<0.01).The MPV and PDW between two groups were no differences(P>0.05).Spearman correlation analysis showed that Plt was positively correlated with ALT,AST,ALP,GGT and ALB(r=0.309,0.294,0.343,0.420,0.368,P<0.05 or 0.01);PCT was positively correlated with ALT,AST,ALP,GGT and ALB(r=0.306,0.301,0.326,0.441,0.387,P<0.05 or 0.01);Plt and PCT were negatively correlated with the prognosis ALBI score(r=-0.298,-0.312,P<0.01).Conclusion Plt and PCT are significantly decreased in patients with PBC,and significantly correlat with biochemical indices as well as ALBI score,which can provide important clues to the preliminary assessment of severity and prognosis in patients with PBC.更多还原