【摘要】 目的:探讨比索洛尔联合贝那普利治疗对高血压合并急性心力衰竭(AHF)患者心电图及左室舒张功能的影响。方法:124例高血压合并AHF患者被随机均分为常规治疗组和联合治疗组(在常规治疗基础上采用比索洛尔联合贝那普利治疗)。治疗2个月,比较两组疗效,治疗前后心电图指标、左室舒张功能指标、心衰及心肌损伤标志物水平变化等。结果:治疗2个月后,联合治疗组总有效率显著高于常规治疗组(96.77%比82.26%,P=0.008);与常规治疗组比较,联合治疗组QRS波时限[(103.87±9.70)ms比(94.12±8.93)ms]、QTc间期[(432.37±33.24) ms比(418.96±29.64) ms]、平面QRS-T夹角[(59.75±26.61)°比(48.19±22.30)°]、二尖瓣环舒张晚期运动峰值速度(Am)[(12.84±3.40) cm/s比(11.39±3.11) cm/s]、血浆N末端脑钠肽前体[(1.20±0.58)μg/L比(0.75±0.47)μg/L]、糖类抗原125 [(19.10±9.24)U/ml比(13.93±7.85) U/ml]、半乳凝素-3[(4.72±2.25)μg/L比(3.28±1.65)μg/L]、心肌肌钙蛋白I [(1.93±0.97)μg/L比(1.46±0.85)μg/L]水平均显著下降,二尖瓣舒张早期与晚期血流峰值速度比值(E/A)[(1.18±0.30)比(1.31±0.28)]、二尖瓣环舒张早期运动峰值速度(Em)[(12.90±3.76) cm/s比(14.49±3.25) cm/s]水平均显著提高,P<0.05或<0.01。两组不良反应发生率无显著差异(P>0.05)。结论:比索洛尔联合贝那普利治疗高血压合并AHF患者疗效显著,且心电图指标与左室舒张功能改善显著。更多还原

【Abstract】 Objective:To explore influence of bisoprolol combined benazepril on ECG and left ventricular diastolic function in hypertensive patients with acute heart failure(AHF). Methods: A total of 124 hypertensive patients with AHF were randomly and equally divided into routine treatment group and combined treatment group(received bisoprolol combined benazepril based on routine treatment), both groups were treated for two months. Therapeutic effect, ECG indexes, left ventricular diastolic function indexes, levels of heart failure and myocardial injury markers etc.before and after treatment were compared between two groups. Results:After two-month treatment, total effective rate of combined treatment group was significantly higher than that of routine treatment group(96.77% vs. 82.26%, P=0.008); compared with routine treatment group, there were significant reductions in QRS wave duration [(103.87±9.70)ms vs.(94.12±8.93)ms], QTc duration [(432.37±33.24) msvs.(418.96±29.64) ms], plane QRS-T angle [(59.75±26.61)° vs.(48.19±22.30)°], mitral annulus late diastolic peak flow velocity(Am) [(12.84±3.40) cm/svs.(11.39±3.11) cm/s], plasma levels of N terminal pro brain natriuretic peptide[(1.20±0.58) μg/L vs.(0.75±0.47) μg/L], carbohydrate antigen 125 [(19.10±9.24)U/ml vs.(13.93±7.85) U/ml], galectin-3 [(4.72±2.25) μg/L vs.(3.28±1.65) μg/L], cardiac troponin I [(1.93±0.97) μg/L vs.(1.46±0.85) μg/L], and significant rise in mitral early/late diastolic peak flow velocity(E/A) [(1.18±0.30) vs.(1.31±0.28)]and mitral annulus early diastolic peak flow velocity(Em)[(12.90±3.76) cm/svs.(14.49±3.25) cm/s] in combined treatment group, P<0.05 or <0.01. There was no significant difference in incidence rates of adverse reactions between two groups, P>0.05 all. Conclusion: Bisoprolol combined benazepril possesses significant therapeutic effect on hypertensive patients with AHF, and its improving effect on ECG indexes and left ventricular diastolic function is significant.更多还原