【摘要】 目的:分析原发性高血压(EH)患者主动脉脉搏波传导速度(APWV)的影响因素。方法:我院336例EH患者被分为APWV升高组(281例)和APWV正常组(55例),对比两组临床资料,采用Logistic多元回归分析EH患者APWV的影响因素。结果:与APWV正常组比较,APWV升高组年龄[(56.71±11.45)岁比(62.98±12.36)岁],糖尿病(5.45%比19.22%)、肥胖(18.18%比23.84%)、吸烟史(16.36%比30.60%)、高血压3级(12.73%比32.03%)比例,人体质量指数(BMI)[(22.53±2.07)kg/m~2比(23.28±2.04) kg/m~2],SBP[(139.64±12.85)mmHg比(147.39±13.30)mmHg]、DBP[(93.18±8.73)mmHg比(96.43±9.14)mmHg],TC[(5.18±0.91)mmol/L比(5.65±1.03)mmol/L]、LDL-C[(3.00±0.68)mmol/L比(3.24±0.72)mmol/L]、SCr[(110.71±52.39)μmol/L比(138.52±63.65)μmol/L]、SUA[(318.73±102.62)μmol/L比(354.28±108.35)μmol/L]水平显著升高,HDL-C(1.19±0.32)mmol/L比(1.09±0.30)mmol/L显著降低(P<0.05或<0.01)。多因素Logistic回归分析显示,年龄、糖尿病、SBP、TC、SCr、高血压等级是影响APWV的独立危险因素(OR=2.826～3.732,P均<0.05)。结论:年龄、糖尿病、SBP、TC、SCr、高血压等级是影响原发性高血压患者APWV的危险因素,因此,应采取相应的防治措施改善预后。更多还原

【Abstract】 Objective:To analyze influencing factors of aortic pulse wave velocity(APWV) in patients with essential hypertension(EH).Methods:The 336 EH patients from our hospital were divided into elevated APWV group(n=281) and normal APWV group(n=55). Clinical data were compared between two groups, and multi-factor Logistic regression was used to analyze influencing factors of APWV in EH patients.Results:Compared with normal APWV group, there were significant rise in age [(56.71±11.45) years vs.(62.98±12.36)years], percentages of diabetes mellitus(5.45% vs. 19.22%), obesity(18.18%vs. 23.84%), smoking(16.36% vs. 30.60%),EH stage 3(12.73% vs. 32.03%), body mass index [BMI,(22.53±2.07)kg/m~2 vs.(23.28±2.04) kg/m~2], systolic blood pressure SBP[(139.64±12.85)mmHg vs.(147.39±13.30)mmHg], diastolic blood pressure DBP[(93.18±8.73)mmHg vs.(96.43±9.14)mmHg], TC[(5.18±0.91)mmol/L vs.(5.65±1.03)mmol/L], LDL-C[(3.00±0.68)mmol/L vs.(3.24±0.72)mmol/L], serum creatinine SCr[(110.71±52.39)μmol/L vs.(138.52±63.65)μmol/L], serum uric acid SUA[(318.73±102.62)μmol/L vs.(354.28±108.35)μmol/L], and significant reduction in level of HDL-C[(1.19±0.32)mmol/Lvs.(1.09±0.30)mmol/L]in elevated APWV group, P<0.05 or <0.01. Multi-factor Logistic regression analysis indicated that age, diabetes mellitus, SBP, TC, SCr and EH stage were independent risk factors for APWV(OR=2.826-3.732,P<0.05 all).Conclusion:Age, diabetes mellitus, SBP, TC, SCr and EH stage are risk factors for APWV in EH patients. Therefore, corresponding preventive and therapeutic measures should be taken to improve prognosis.更多还原