【摘要】 目的:研究缬沙坦联合氢氯噻嗪对高血压患者24h舒张压(DBP)、24h收缩压(SBP)及血压变异性的影响。方法:我院接受治疗的高血压患者94例,被随机均分为缬沙坦组与联合治疗组(缬沙坦联合氢氯噻嗪治疗),各47例。两组均进行1个月的治疗。对比治疗前后两组24hDBP、24hSBP、血压变异性,一氧化氮和内皮素水平变化以及不良反应发生率。结果:治疗后,与缬沙坦组比较,联合治疗组24hSBP[(130.64±10.01) mmHg比(121.53±9.35) mmHg]、24h舒张压变异性(DBPV)[(12.47±3.32)%比(10.82±2.71)%]、24h收缩压变异性(SBPV)[(10.42±2.00)%比(8.51±1.64)%]以及白昼SBPV[(10.87±2.05)%比(8.66±1.65)%]均明显降低(P<0.05或<0.01);一氧化氮水平[(42.92±6.84)μmol/L比(53.43±7.16)μmol/L]显著升高,内皮素水平[(38.62±5.52) ng/L比(31.01±5.01) ng/L]显著降低(P均=0.001)。两组不良反应发生率无显著差异(P均>0.05)。结论:缬沙坦联合氢氯噻嗪应用于高血压患者中可有效改善24hDBP、24hSBP水平以及血压变异性,且有利于调节一氧化氮与内皮素水平。更多还原

【Abstract】 Objective: To study influence of valsartan combined hydrochlorothiazide on 24 h diastolic blood pressure(DBP), 24 h systolic blood pressure(SBP) and blood pressure variability(BPV) in patients with hypertension. Methods:A total of 94 hypertensive patients treated in our hospital were randomly and equally divided into valsartan group and combined treatment group(received valsartan combined hydrochlorothiazide), both groups were treated for one month. The 24 hDBP, 24 hSBP, BPV, levels of nitric oxide(NO) and endothelin(ET) before and after treatment and incidence of adverse reactions were compared between two groups. Results:Compared with valsartan group after treatment, there were significant reductions in 24 hSBP [(130.64±10.01) mmHg vs.(121.53±9.35) mmHg], 24 h DBP variability(24 hDBPV) [(12.47±3.32)% vs.(10.82±2.71)%], 24 hSBPV [(10.42±2.00)% vs.(8.51±1.64)%] and daytime SBPV [(10.87±2.05)% vs.(8.66±1.65)%], P<0.05 or <0.01; significant rise in NO level [(42.92±6.84) μmol/L vs.(53.43±7.16) μmol/L] and significant reduction in ET level [(38.62±5.52) ng/L vs.(31.01±5.01) ng/L] in combined treatment group, P=0.001 both. There were no significant difference in incidence of adverse reactions between two groups, P>0.05 all. Conclusion:Valsartan combined hydrochlorothiazide can effectively improve levels of 24 hDBP, 24 hSBP and blood pressure variability, and contribute to regulating NO and ET levels in patients with hypertension.更多还原