【摘要】 目的探讨利伐沙班在预防ICU患者静脉血栓栓塞症(VTE)的应用价值。方法选取2015年06月至2016年12月我院收治的高危VTE风险的患者120例,采用电脑产生随机数法将患者分为治疗组n=60例和对照组n=60例。治疗组采用利伐沙班预防血栓,对照组采用低相对分子质量肝素钙预防血栓,观察和记录治疗组和对照组患者VTE症的发生情况、aPTT、PT、PLT及药物的不良反应情况。结果治疗组患者中发生VTE共计6例,发生率为10.0%低于对照组的26.7%(P<0.05),治疗组不良反应发生率为10.0%低于观察组11.7%,但差异无统计学意义(P>0.05),未发现治疗前后观察组和对照组aPTT、PT、PLT存在统计学差异(P>0.05)。结论利伐沙班在预防ICU静脉血栓栓塞症效果较好,能减少ICU患者VTE的发生率。更多还原

【Abstract】 Objective To explore the application value of Rivaroxaban in the prevention of venous thromboembolism(VTE)in ICU patients.Methods 120 patients with high risk VTE in our hospital from June 2015 to December 2016 were selected,and the patients were divided into treatment groupn=60 Cases and control Groupn=60 Cases by Computer generation random number method.The treatment group used Rivaroxaban to prevent thrombosis,the control group used low molecular heparin calcium(LMWH-ca)to prevent thrombosis,observe and record the occurrence of VTE,aPTT,PT,PLT and drug adverse reactions in the treatment group and control group.Results VTE occurred in the treatment group in 6 cases,the incidence was 10% lower than that of the control group 26.7%(P<0.05),the incidence of adverse reactions in the treatment group was 10% lower than that of the observation group 11.7%,but the difference was not statistically significant(P>0.05),and there were no statistical differences between the observation group and the control group aPTT,PT and PLT before and after treatment(P>0.05).Conclusion Rivaroxaban is effective in preventing VTE,which can reduce the incidence of VTE in ICU.更多还原