【摘要】 目的探讨低分子肝素钠治疗复发性流产的临床效果。方法选取2016年12月至2017年12月鄂东医疗集团黄石市妇幼保健院、鄂东医疗集团黄石市中心医院和湖北省妇幼保健院接受治疗的90例复发性流产患者作为研究对象。采用随机数字表法实施分组,对照组45例,给予常规治疗;观察组45例,在对照组基础上加用低分子肝素钠治疗。对两组患者治疗前后的各项临床指标、妊娠并发症发生情况以及不良反应发生情况进行综合评价。结果观察组患者治疗后的凝血酶原时间(PT)、凝血酶时间(TT)等水平均有所改善,显著优于对照组,差异具有统计学意义(P<0.05);观察组患者治疗后的妊娠并发症率为6.67%,与对照组对比差异具有统计学意义(P<0.05);且观察组治疗后有4例患者存在不良反应,占8.89%,显著低于对照组的26.67%,两组差异具有统计学意义(P<0.05)。结论低分子肝素钠治疗复发性流产,能够提升妊娠结局,促进患者各项指标改善,不良反应少,值得临床推广应用。更多还原

【Abstract】 Objective To investigate the clinical effect of low molecular weight heparin sodium in the treatment of recurrent spontaneous abortion. Methods 90 patients with recurrent spontaneous abortion undergoing treatment in Huangshi Maternal and Child Health Care Hospital, Huangshi Central Hospital and Hubei Maternal and Child Health Hospital from December 2016 to December 2017 were selected as study subjects. The patients were divided into two groups according to random number table. The control group(n=45) was given routine treatment. The observation group(n=45) received low molecular weight heparin sodium treatment on the basis of routine treatment. Clinical indicators before and after treatment, pregnancy complications and adverse reactions of the two groups were comprehensively evaluated. Results After treatment, the prothrombin time(PT) and thrombin time(TT) in observation group improved significantly, which was significantly better than that in control group(P<0.05), with statistically significant differences. After treatment, incidence of pregnancy complications in the observation group was 6.67%,with statistically significant difference between the two groups(P<0.05).There were 4 cases of adverse reactionsin the observation group(8.89%), significantly lower than that of control group(26.67%), with statistically significant differences(P<0.05). Conclusions Low molecular weight heparin sodium treatment of recurrent spontaneous abortion, can improve pregnancy outcomes and the indicators of patients with few adverse reactions, which is worthy of clinical application.更多还原