【摘要】 目的探讨IL-1、β2防御素及CRP联合检测对未足月胎膜早破孕妇绒毛膜羊膜炎的临床诊断价值。方法选取2015年1月至2017年1月武汉市蔡甸区人民医院诊治的未足月胎膜早破(PPROM)孕妇91例和未足月健康孕妇45例作为研究对象。根据患者是否合并绒毛膜羊膜炎(HCA)分为HCA组和非HCA组,HCA组患者50例,非HCA组患者41例。其中又根据HCA严重程度分为轻度组、中度组和重度组,轻度组患者19例,中度组患者17例,重度组患者15例。同时还随机选取同期于武汉市蔡甸区人民医院做产前检查的正常未足月孕妇45例为对照组。测定各组孕妇血清IL-1、β2防御素及CRP含量,对比联合检测与单独检测对诊断PPROM孕妇HCA的差别。结果 HCA组3指标值分别为(0.98±0.13)ng/L、(2.84±0.41)ng/L和(25.73±7.91)mg/L,显著高于非HCA组及对照组,经统计学分析差异有统计学意义(P<0.05)。根据HCA程度分组,重度组3项指标值分别为(0.91±0.21)ng/L、(2.01±0.68)ng/L和(19.89±7.94)mg/L,显著高于其余两组,经统计学分析差异有统计学意义(P<0.05)。此外,联合检测3项指标时,敏感性及特异性均显著高于单独检测组,经统计学分析差异有统计学意义(均P<0.05)。结论 IL-1、β2防御素及CRP水平与PPROM合并HCA的发生及发展密切相关,动态监测上述指标可提高疾病早期诊出率,降低不良妊娠的发生。更多还原

【Abstract】 Objective To investigatethe diagnostic value of combined detection of IL-1, human defensinβ2 and CRP in pregnant women with preterm premature rupture of membranes combined with chorioamnionitis. Methods 91 pregnant women with preterm premature rupture of membranes in our hospital from January 2015 to January 2017 were selected and divided into HCA group(n=51) and non-HCA group(n=40), according to the severe degree. The HCA group were further divided to three groups,which were mild(n=19), moderate(n=17) and severe(n=15). Besides, 45 healthy pregnant women went to the hospital for prenatal examinationat the same time were selected as control group. The levels of serum IL-1,human defensin β2 and CRP were detected and compared. Results The three indexes of HCA group [(0.98±0.13)ng/L,(2.84±0.41) ng/L and(25.73±7.91) mg/L] was significantly higher than those of non-HCA group and control group, with statistically significant differences(P<0.05). The three indexes of the severe HAC group [(0.91±0.21) ng/L,(2.01±0.68) ng/L and(19.89±7.94)mg/L] were significantly higher than those of the other two groups, with statistically significant differences(P<0.05). In addition, the sensitivity and specificity of the three indexes in combined detection were significantly higher than those of the individual test group, with statistically significant differences(P<0.05).Conclusions Serum IL-1,human defensin β2 and CRP were closely related to the occurrence and development of PPROM combined with HCA, so monitoring of the above indicators is conductive to improving pregnancy outcomes.更多还原