【摘要】 目的探讨连续硬膜外麻醉下高频电刀结合微波治疗肛周尖锐湿疣的临床效果及对患者性生活质量的影响。方法选择2013年5月至2017年6月宜宾市第二人民医院诊治的60例肛周尖锐湿疣患者作为研究对象,将其随机分为观察组和对照组,每组30例患者。观察组患者在对照组治疗基础上联合微波治疗,对照组在连续硬膜外麻醉下实施高频电刀治疗。采用酶联免疫吸附试验,测定两组患者治疗前、治疗后白细胞介素-2(IL-2)、干扰素-r(IFN-r)和白细胞介素-6(IL-6)水平;采用性功能评价量表(BISF-W)对两组患者治疗前、治疗后性生活质量进行评估。比较两组患者疗效及对患者性生活质量的影响。结果观察组患者治疗后6个月的效率高于对照组患者,其差异具有统计学意义(P<0.05);两组患者治疗前性生活质量评分差异无统计学意义(P>0.05);观察组患者治疗后BISF-W各项评分均高于对照组患者(均P<0.05)。结论连续硬膜外麻醉下采用高频电刀结合微波治疗肛周尖锐湿疣效果理想,值得临床推广应用。更多还原

【Abstract】 Objective To investigate the clinical effect of high frequency electric knife under continuous epidural anesthesia combined with microwave therapy for patients with perianal condyloma acuminatum(CA) and its influence on the quality of sexual life. Methods 60 patients with perianal CA treated in the Second People′s Hospital of Yibin from May 2013 to June 2017 were randomly divided into the control group(n=30) and observation group(n=30). Patients in the control group received high frequency electric knife under continuous epidural anesthesia, on which basis patients in the observation group received microwave treatment. The levels of interleukin-2(IL-2), interferon-r(IFN-r) and interleukin-6(IL-6) in the two groups were measured by enzyme-linked immunosorbent assay before and after treatment. Sexual function was measured with Brief Index of Sexual Function for Women(BISF-W) in the 2 groups before and after treatment to compare the influence of treatment on the quality of sexual life. Results The treatment efficiency in the observation group at 6 months after treatment was higher than that of control group, with statistically significant difference(P<0.05). There was no statistically significant difference in the BISF-W between the 2 groups before treatment(P>0.05), while the BISF-W scores in the observation group after treatment were higher than those in the control group(all P<0.05). Conclusions High frequency electric knife under continuous epidural anesthesia combined with microwave therapy is ideal for patients with perianal CA, which is worthy of popularization and application.更多还原