【摘要】 目的探讨血清成纤维细胞生长因子23(FGF-23)在维持性血液透析患者血管钙化中的作用。方法选择2016年5月-2018年5月在新疆医科大学第五附属医院接受临床治疗的维持性血液透析患者116例(观察组),选取116例前来医院体检的正常人作为对照组。对比2组患者的平滑肌细胞(VSMCs)钙含量、碱性磷酸酶(ALP)活性以及血清成纤维细胞生长因子(FGF-23)的差异。结果观察组FGF-23、VSMCs以及ALP活性水平明显高于对照组,差异均有统计学意义(P<0.05)。结论在维持性血液透析患者中,FGF-23可反映出患者的血管钙化情况,属于血管钙化的重要指标之一,值得在临床中应用推广。更多还原

【Abstract】 Objective To study the role of serum fibroblast growth factor 23 in vascular calcification in maintenance hemodialysis patients. Methods 116 maintenance hemodialysis patients(observation group) who received clinical treatment in the Fifth Affiliated Hospital of Xinjiang Medical University from May 2016 to May 2018 were selected as the control group, and 116 normal persons who came to the hospital for physical examination were selected as the control group. The differences of calcium content, alkaline phosphatase(ALP) activity and serum fibroblast growth factor(FGF-23) in smooth muscle cells(VSMCs) between the two groups were compared. Results The levels of fibroblast growth factor-23, VSMCs and ALP in the observation group were significantly higher than those in the control group(P<0.05). Conclusion In maintenance hemodialysis patients, FGF-23 can reflect the vascular calcification of patients in time, which is one of the important indicators of vascular calcification and is worthy of application in clinical practice.更多还原