【摘要】 目的应用实时剪切波超声弹性成像技术测定不同亚型原发性帕金森病(PD)患者肱二头肌、股四头肌的杨氏模量值,探讨不同亚型PD患者肌张力情况。方法选取原发性PD患者100例,按照标准分为震颤组48例,姿势异常步态障碍(PIGD)组52例,选择60名健康体检者为对照组,应用实时定量剪切波弹性成像测定各组患者双侧肱二头肌及股四头肌的杨氏模量,探讨不同亚型的PD患者双侧肱二头肌、股四头肌杨氏模量值的差异。结果 1.松弛状态下,震颤组和PIG组患者双侧肱二头肌和股四头肌的杨氏模量值高于对照组(P <0.05);且PIGD P <0.05)。结论实时定量剪切波弹性成像技术可检测出不同亚型帕金森病患者肱二头肌、股四头肌杨氏模量值的差异,PIGD为主型PD的患者肌张力高于震颤为主型PD的患者,为指导临床治疗提供更多的依据。更多还原

【Abstract】 Objective To determine Young’s modulus of biceps brachii and quadriceps femoris in patients with different subtypes of primary Parkinson’s disease(PD)by real-time shear wave ultrasound elastography, and to investigate the muscle tension in patients with different subtypes of PD. Methods 100 patients with primary PD were divided into the tremor group(48 cases), the abnormal posture gait disorder(PIGD) group(52 cases) and the control group(60 cases). The Young’s modulus of biceps brachii and quadriceps femoris was measured by real-time quantitative shear wave elastography in each group. The difference of Young’s modulus of biceps brachii and quadriceps femoris in different subtypes of PD patients was discussed. Results 1. Under relaxation status,Young’s modulus of biceps brachii and quadriceps femoris in the tremor group and the PIG group was higher than that of the control group(P < 0.05), and PIGD P < 0.05. Conclusion Real-time quantitative shear wave elastography can detect the difference of Young’s modulus of biceps brachii and quadriceps femoris in patients with different subtypes of Parkinson’s disease. The muscle tension of patients with PIGD-based PD is higher than that of patients with tremor-based PD, which provides more evidence for guiding clinical treatment.更多还原