【摘要】 目的探讨β-trophin在非酒精性脂肪性肝病(NAFLD)发病机制中的作用。方法选取我院2016年1月～2016年8月收治的100例NAFLD患者(NAFLD组)和50例同期于我院体检正常者(对照组)作为研究对象。用回顾性分析法分析所有纳入研究者的临床资料,包括腹部B超检查和血清β-trophin及肝肾功能等相关生化指标水平等。根据B超检查结果将100例NAFLD患者分为轻度、中度和重度,并比较不同纳入研究者上述资料的差异及分析血清β-trophin与其他指标相关性。结果两组Cr、BUN和UA水平比较差异无统计学意义(P>0.05); NAFLD组血清β-trophin、AST和ALT水平均高于对照组,且随着其病情加重,上述指标水平更高(P<0.05);两组FPG水平比较差异无统计学意义(P>0.05);NAFLD组TG、LDL-c、FINS、HbAlc和HOMA-IR水平均高于对照组,而HDL-C较对照组降低,且随着病情越严重,其上述指标上升和降低程度越大(P<0.05);血清β-trophin与AST、ALT、TG、LDL-c、FINS、HbAlc和HOMA-IR呈正相关,与HDL-C呈负相关(P<0.05)。结论β-trophin可能在胰岛素抵抗以及脂代谢调节方面具有一定的生化作用,从而导致NAFLD的发生和进展。更多还原

【Abstract】 Objective To investigate the association between β-trophin and non-alcoholic fatty liver disease(NAFLD). Methods 100 patients with NAFLD(test group) and 50 patients with normal physical examination(control group) treated in our hospital from January 2016 to August 2016 were selected as study subjects. Retrospective analysis was used to analyze the clinical value and follow-up data of all the investigators. All patients underwent abdominal B-ultrasound examination, and detection of serum β-trophin, liver and kidney function related biochemical indicators. According to B-ultrasound results, 100 patients with NAFLD were classified as mild, moderate and severe, compare the differences in the above data among different investigators and analyze the correlation between serum β-trophin and other indicators. Investigate the relationship between serum β-trophin expression and NAFLD. Results There was no difference in levels of Cr, BUN, and UA between the control group and NAFLD patients(P>0.05). However, the levels of serum β-trophin, AST, and ALT in patients with NAFLD were significantly higher than those in the control group. And as the condition worsens, the above indicators are higher(P<0.05). There was no difference in the FPG level between the control group and NAFLD patients(P>0.05). However, the levels of TG, LDL-c, FINS, HbAlc and HOMA-IR in NAFLD patients were significantly higher than those in the control group, and HDL-C was lower than that in the control group, with the severity of the disease, the above indicators increased and decreased greater, and the differences were statistically significant(P<0.05). Spearman rank correlation analysis showed that serum β-trophin was positively correlated with AST, ALT, TG, LDL-c, FINS, HbAlc, and HOMA-IR, but negatively correlated with HDL-C(P<0.05). Conclusion Serum level of β-trophin in NAFLD patients are significantly higher than those in normal subjects, and are positively correlated with AST, ALT, TG, LDL-c, FINS, HbAlc, and HOMA-IR. It is believed that β-trophin may have a certain biochemical effect on insulin resistance and lipid metabolism, resulting in the occurrence and progression of NAFLD.更多还原