【摘要】 阿尔茨海默病(Alzheimer’s disease,AD)是一种进行性发展的神经退行性疾病,严重影响患者的生活质量,给社会和家庭带来沉重负担。随着人口老龄化进程的不断加剧,AD已成为国内外关注的热点和焦点。动物模型对于探明AD病因、发病机制和防治药物的研究具有重要意义。本文主要介绍并比较近年来常用的AD动物模型,以期为研究者选择合适的AD动物模型提供参考。更多还原

【Abstract】 Alzheimer’s disease(AD)is a neurological,degenerative and progressive disorder that destroys memory and other important cognitive functions.Treating AD has become a healthcare and societal priority and the cost of care and the burden on society and caregivers keep increasing.However,it is still irremediable yet and has become one of the focuses of domestic and international researches.Animal models are of great significance for experimental researches on etiology,pathology,and medicine of AD.In this article,we introduce and compare the commonly-used animal models of AD in a bid to provide references for the further studies on AD.更多还原