【摘要】 目的研究帕金森(PD)患者非运动症状对远期认知功能的影响。方法纳入符合标准的PD患者64例,其中男性37例,采用帕金森病综合评量表的第一部分评估患者的非运动症状(NMS),MMSE评估患者的总体认知功能,对基线的非运动症状与2年后的MMSE总分行多因素回归分析。结果调整性别、年龄、教育水平、高血压病史、糖尿病病史、H-Y分级和PD病程后,基线NMS对总体认知功能的回归分析β=-1. 1; 95%CI=(-1. 8,-0. 4); P=0. 005。结论非运动症状增加2年后总体认知功能受损的风险。更多还原

【Abstract】 Objective To study the effect of non-motor symptoms( NMS) on 2-years cognitive function in Parkinson’s patients( PD). Methods In the study,64 PD patients were enrolled. The NMS were assessed by the first part of the Parkinson’s Disease Comprehensive Rating Scale( UPDRS-I). The global cognitive function was assessed by MMSE.Statistical analysis used multivariate regression analysis. Results After adjusted for gender,age,education,hypertension history,diabetes history,H-Y classification and PD course,the regression analysis β( 95% CI) P of baseline NMS for global cognitive function was-1. 1(-1. 8,-0. 4) 0. 005. Conclusion For PD patients,the motor symptoms increase the risk of 2-years global cognitive impairment.更多还原