【摘要】 目的研究癌胚抗原相关粘6(附因子CEACAM6)与基质金属蛋白酶-9(MMP-9)在口腔鳞癌组织中的表达及其临床意义。方法采用免疫组化的方法检测70例口腔鳞癌组织和30例正常口腔黏膜组织中CEACAM6和MMP-9的蛋白表达,分析其与口腔鳞癌临床病理参数的关系及二者的相关性。结果 CEACAM6和MMP-9在口腔鳞癌组织中表达阳性率分别为71.43%(50/70)74.29%(52/70),在正常口腔黏膜组织中表达阳性率分别为16.67%(5/30)、13.33%(4/30)。CEACAM6和MMP-9在口腔鳞癌组织中阳性表达率均高于正常口腔黏膜组织(P<0.05)。高表达的CEACAM6和MMP-9与口腔鳞癌的组织分化程度以及TNM分期有密切相关性(P<0.05),但与患者的性别、年龄、吸烟及肿瘤大小无相关性(P>0.05)。口腔鳞癌组织中CEACAM6与MMP-9的表达呈显著正相关(r=4.712,P<0.05)。结论 CEACAM6和MMP-9在口腔鳞癌中均呈高表达,参与了口腔鳞癌的发生发展,并可能为口腔鳞癌未来阶段的诊断、治疗、预后等提供重要依据。更多还原

【Abstract】 Objective To investigate the expression and clinical significance of carcinoembryonic antigenassociated adhesion factor6(CEACAM6) and matrix metalloproteinase-9(MMP-9) in oral squamous cell carcinoma.Methods The expressions of CEACAM6 and MMP-9 in 70 oral squamous cell carcinoma tissues and 30 normal oral mucosa tissues were detected by immunohistochemistry. The relationship between CEACAM6 and MMP-9 expression in oral squamous cell carcinoma and the correlation between them were analyzed. Results The positive rates of CEACAM6 and MMP-9 in oral squamous cell carcinoma were 71.43%(50/70) 74.29%(52/70), respectively, and the positive expression rates in normal oral mucosa were 16.67%(5/30), 13.33%(4/30). The positive expression rates of CEACAM6 and MMP-9 in oral squamous cell carcinoma were higher than those in normal oral mucosa(P<0.05). Highly expressed CEACAM6 and MMP-9 were closely related to the degree of tissue differentiation and TNM staging of oral squamous cell carcinoma(P<0.05), but were not associated with gender, age, smoking and tumor size(P>0.05). There was a significant positive correlation between CEACAM6 and MMP-9 expression in oral squamous cell carcinoma(r=4.712, P<0.05). Conclusion CEACAM6 and MMP-9 are highly expressed in oral squamous cell carcinoma, which is involved in the development of oral squamous cell carcinoma and may provide important evidence for the diagnosis, treatment and prognosis of oral squamous cell carcinoma in the future.更多还原