【摘要】 目的明确游泳运动是否可抑制高碳水化合物和脂肪饮食(HCFD)诱导肥胖大鼠凝血功能异常。方法 40只雄性Wistar大鼠被随机分为4组,对照组、对照+游泳组、HCFD组和HCFD+游泳组。各组大鼠均饲养15周,其中对照组大鼠用标准实验室饲料喂养15周;HCFD组大鼠HCFD饲养15周。游泳组大鼠在第11周到第15周进行游泳训练。然后分别对各组大鼠炎性标志物和凝血相关指标等进行检测。结果 HCFD导致大鼠血糖、IR、血脂异常和炎性生物标志物显著增高。此外,HCFD显著增加大鼠凝血和血栓形成生物标志物,如纤维蛋白原、纤溶酶原激活剂抑制物-1、凝血酶原时间、活化部分凝血活酶时间、凝血和出血时间以及血小板聚集等,而游泳运动可抑制HCFD大鼠上述指标的增加。结论在肥胖和IR大鼠模型中,通过游泳运动可以改善凝血功能异常。更多还原

【Abstract】 Objective To determine whether swim exercise can inhibit high carbohydrate and fat diet（HCFD）-induced biomarkers of coagulation. Methods 40 male Wistar rats were randomly divided into 4 groups: control group, control + swimming group, HCFD group, and HCFD+ swimming group. Rats of control group were fed with standard laboratory chow for 15 weeks, and rats of HCFD group were fed HCFD for 15 weeks. Swim exercise-‘treated’ rats started swim exercise training from the 11^th week until being sacrificed, on week 15.Then inflammatory markers and coagulation related indicators were detected in each group. Results HCFD caused a significant increase in blood glucose, insulin resistance（IR）, lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and platelet aggregation that was effectively inhibited by swimming exercises. Conclusions In an animal model of obesity and IR, there is a significant change in hemostasis, which is ameliorated by swim exercise.更多还原