【摘要】 目的比较甲泼尼松龙和99Tc-MDP治疗Graves眼病的疗效。方法选择2012年1月—2016年10月在大同市第五人民医院住院治疗的甲状腺相关眼病(Graves ophthalmopathy,简称GO)患者共60例。随机分为甲泼尼龙治疗组即激素组(30例)和99Tc-MDP组(30例),激素组应用甲泼尼龙500 mg溶于0.9%氯化钠注射液100 mL,静脉滴注,1次/日,连续3日,每隔4天再继续静脉滴注3天,连续3次,99Tc-MDP组将99Tc-MDP 10 mg,A剂注入B剂瓶内,充分混匀,在室温下静置5 min后加入生理盐水250 mL中静脉缓慢滴入,2～3 h滴完,21 d为1疗程。治疗前后比较患者自觉症状、突眼度、复视等的改善情况。结果激素组总有效率在GO活动性、突眼度、复视及眼球运动障碍的改善方面高于99Tc-MDP组(χ2=4.800,4.593,4.509,3.976,P=0.028,0.032,0.034,0.046)。结论甲泼尼龙治疗GO优于99Tc-MDP。更多还原

【Abstract】 Objective To compare the clinical efficacy of ⁹⁹Tc-MDP and methylprednisolone in treatment of Graves’ ophthalmopathy. Methods 60 patients with thyroid-associated ophthalmopathy were enrolled, who were hospitalized form January 2012 to October 2016 and randomly divided into the methylprednisolone therapy group（hormone group, 30 cases） and ⁹⁹Tc-MDP group（30 cases）. Hormone group was treated with methylprednisolone 500 mg dissolved in 100 mL of 0.9% sodium chloride injection, intravenous drip, once a day, 3 consecutive days, after 4 days to continue intravenous drip for 3 days, altogether for 3 consecutive times. In ⁹⁹Tc-MDP group, ⁹⁹Tc-MDP was injected with 10 mg of agent A into the bottle of agent B, added to normal saline 250 mL, after 5 minutes at room temperature, ⁹⁹Tc-MDP was venous slowness Uniform infusion for 2～3 hours, 21 days for 1 courses. The improvement of conscious symptoms, exophthalmos and diplopia were compared before and after treatment. Results The total effective rate of the hormone group was significantly higher than that of the ⁹⁹Tc-MDP group in the improvement of GO activity, exophthalmos, diplopia and ocular movement disorders（χ2=4.800, 4.593, 4.509, 3.976, P=0.028, 0.032, 0.034, 0.046）. Conclusion The effect of methylprednisolone is better than ⁹⁹Tc-MDP in treatment of Graves’ ophthalmopathy.更多还原