【摘要】 目的比较完全胸腔镜下解剖性肺段切除术与肺叶切除术治疗肺部小结节的近期疗效。方法研究对象为我院52例肺部小结节患者。全部患者均接受肺功能及支气管舒张试验、胸部HRCT及诱导痰检查。根据手术方法不同分为2组:对照组23例运用肺叶切除术治疗,观察组29例运用完全胸腔镜下解剖性肺段切除术治疗。对两组患者临床资料、肺功能进行组间对比分析。对肺气肿程度与气道炎症细胞和细胞因子水平进行相关分析。结果观察组FEV1%pred、DLCO%pred、DLCO/VANpred较对照组明显升高(P<0.001),而RV/TLC及RV%pred较对照组明显下降(P <0.005)。结论完全胸腔镜下解剖性肺段切除术治疗肺部小结节近期效果显著,能够有效提高患者肺功能,值得临床推广应用。更多还原

【Abstract】 Objective to compare short-term effect of total thoracoscopic segmental resection and lobectomy in treatment of small pulmonary nodules. Methods treat 52 cases pulmonary nodules patients as research objects. All patients received lung function and bronchodilation test, chest HRCT and induced sputum examination. According to different operation methods, divide them into two groups: control group(23 cases) was treated with lobectomy, observation group(29 cases) with total thoracoscopic segmental resection. Compare linical data and pulmonary function of two groups. Analyze correlation between emphysema degree and airway inflammatory cells and cytokines level. Results FEV1% PRED, DLCO% PRED and DLCO/vanpred in observation group was significantly higher than control group(P< 0.001), while RV/TLC and RV% PRED significantly lower than control group(P< 0.005). Conclusion total thoracoscopic segmental resection has significant effectin treatment of small pulmonary nodules, can improve lung function of patients effectively, which is worthy of clinical promotion and application.更多还原