【摘要】 目的分析探讨经支气管冷冻肺活检术在不明原因肺弥漫性病变的临床诊断价值。方法选取2018年6月至2019年6月我院收治的14例肺部弥漫性病变患者,对其应用经支气管冷冻活检术资料进行回顾性分析,作为观察组,同时选取同期应用钳夹活检的肺部弥漫性病变患者15例,作为对照组。观察对比两组患者组织病理诊断资料。结果病理报告显示,观察组中,2例被确诊为腺癌、3例为非特异性间质性肺炎(NSIP)、3例为免疫相关性间质性肺炎、1例患者为多耐药近平滑假丝酵母菌肺炎、1例患者为肺结核。观察组患者的诊断符合率为71.43%(10/14);对照组中,2例被确诊为腺癌、2例为NSIP,3例为免疫相关性间质性肺炎。对照组患者诊断符合率为46.67%(7/15),两组对比,其诊断符合率差异有统计学意义(P<0.05)。此外,观察组患者组织标本其直径显著大于对照组,差异有统计学意义(P<0.05)。但观察组与对照组出血情况对比,差异无统计学意义(P>0.05)。结论应用经支气管冷冻肺活检术,可对肺部弥漫性病变进行准确的诊断,其诊断符合率较高,出血量少,是一种安全、高效的活检方式更多还原

【Abstract】 Objective To explore the clinical value of transbronchial frozen lung biopsy in the diagnosis of diffuse lung lesions of unknown origin.Methods Fourteen patients with diffuse pulmonary lesions admitted to our hospital from June 2018 to June 2019 were enrolled.The patients underwent retrospective analysis using transbronchial biopsy data as observation group and concurrent application of clamps.Fifteen patients with diffuse lung lesions under biopsy served as a control group.The histopathological diagnosis data of the two groups were observed and compared.Results Pathological reports showed that 2 patients were diagnosed with mucinous adenocarcinoma,3 with non-specific interstitial pneumonia(NSIP),3 with immune-related interstitial pneumonia,and 1 with alveolar cell carcinoma.One patient was tuberculosis.The diagnostic coincidence rate of the observation group was 71.43%(10/14);in the control group,2 cases were diagnosed as mucinous adenocarcinoma,2 cases were NSIP,and 3 cases were immune-related interstitial pneumonia.The diagnostic coincidence rate of the control group was 46.67%(7/15).There was a statistically significant difference in the diagnostic coincidence rate between the two groups(P<0.05).In addition,the diameter of the tissue samples of the observation group was significantly larger than that of the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the bleeding between the observation group and the control group(P>0.05).Conclusion The application of transbronchial frozen lung biopsy can accurately diagnose diffuse lung lesions.It has a high diagnostic coincidence rate and low bleeding volume.It is a safe and effective biopsy method.更多还原