【摘要】 目的探讨术前血清CA125水平与肝癌临床病理特征及预后的关系。方法采用回顾性分析,选择广西医科大学附属肿瘤医院2014年1月至2015年11月收治的232例肝癌患者,用卡方检验的方法研究术前血清CA125水平与一系列临床特征的关系,用Kaplan-Meier法做生存曲线研究术前血清CA125水平高低与肝癌生存时间的关联,用Cox回归模型行术前血清CA125水平及临床特征单因素和多因素分析。结果在一系列的临床特征中,患者是否合并门脉癌栓、肿瘤包膜是否完整、肿瘤直径是否大于5 cm,其血清CA125水平有统计学差异(P<0.05),绘制生存分析曲线证明术前血清CA125水平与肝癌患者预后相关,术前CA125水平正常组平均生存时间较CEA水平增高组长(χ~2=15.209,P <0.001),单因素分析显示,门脉癌栓、肿瘤包膜、肿瘤直径、肿瘤数目、AFP、CA125和BCLC分期是影响肝癌患者术后预后的危险因素。多因素分析显示,肿瘤直径、肿瘤数目和CA125可能是影响肝癌术后预后的独立危险因素。结论术前血清CA125水平是肝癌预后不良的独立危险因素,肿瘤直径大与5cm、包膜不完整、并发门脉癌栓患者术前血清CA125水平更高。更多还原

【Abstract】 Objective to investigate relationship between preoperative serum CA125 level and clinicopathological features and prognosis of hepatocellular carcinoma(HCC). Methods review and analyse 232 cases HCC patients admitted to Guangxi Medical University Affiliated Tumor Hospital from January 2014 to November 2015. Study relationship between preoperative serum CA125 level and a series of clinical features by chi-square test, and relationship between preoperative serum CA125 level and survival curve by survial curve of Kaplan-Meier method. Analyze univariate and multivariate factors correlation between serum CA125 level and clinical features by Cox regression model. Results among a series of clinical features, serum CA125 level with portal vein cancer thrombus, complete tumor capsule, tumor diameter larger than 5 cm or not showed statistical significance,(P< 0.05). Survival analysis curve showed preoperative serum CA125 level was correlated with prognosis of hepatocellular carcinoma patients.Average survival time of normal preoperative CA125 level was longer than CEA level increase group,(χ~2=15.209,P < 0.05). Univariate analysis showed portal vein cancer thrombus, tumor capsule, tumor diameter, tumor numbers,AFP, CA125 and BCLC staging were risk factors affecting prognosis of hepatocellular carcinoma patients. Multivariate analysis showed tumor diameter, tumor numbers and CA125 may be independent risk factors affecting prognosis of hepatocellular carcinoma. Conclusion preoperative serum CA125 level is an independent risk factor of poor prognosis of hepatocellular carcinoma, which is higher for patients with 5 cm tumor diameter above, incomplete capsule and complicated with portal vein cancer thrombus.更多还原