【摘要】 Wnt信号通路异常激活和恶性肿瘤的发病关系密切,WIF-1基因是Wnt信号通路的一个抑制因子,能和Wnt蛋白受体直接结合从而抑制了Wnt通路的异常激活,起到抑制肿瘤的作用,但是很多研究发现,在恶性肿瘤中WIF-1基因表达沉默,而这种沉默和其CpG岛甲基化的程度密不可分。本文就恶性肿瘤和WIF-1的关系的临床研究做出综述。更多还原

【Abstract】 The abnormal activation of Wnt signaling pathway is closely related to the pathogenesis of malignant tumor. WIF-1 gene is an inhibitor of Wnt signaling pathway and can directly bind to Wnt protein receptor, thereby inhibiting the abnormal activation of Wnt pathway and inhibiting tumor. Role, but many studies have found that WIF-1 gene expression is silenced in malignant tumors, and this silence is inextricably linked to the extent of its CpG island methylation. This article reviews the clinical study of the relationship between malignant tumors and WIF-1.更多还原