【摘要】 目的探讨祛风活血解郁法治疗药物过度使用性头痛(MOH)的临床效果。方法选取2012年8月至2014年10月在成都中医药大学附属医院神经内科就诊的60例MOH患者作为研究对象,用随机数字表法分为治疗组(30例)和对照组(30例),两组基础治疗为撤药并进行MOH宣教,必要时服用双氯芬酸钠或萘普生等止痛。治疗组使用柴芎止痛汤,对照组使用盐酸氟桂利嗪。治疗时间3个月,治疗结束后对两组患者头痛程度、头痛发作天数、中医症候得分等指标进行比较。结果两组头痛程度、头痛发作天数、中医症候评分在治疗后与治疗前比较均有下降,差异有统计学意义(P<0.05);治疗后头痛程度和头痛发作天数治疗组与对照组组间比较差异无统计学意义(P>0.05);中医症候评分中治疗组郁证得分在治疗后低于于对照组,差异有统计学意义(P<0.05),而治疗后风症、瘀血证得分治疗组与对照组比较差异无统计学意义(P>0.05)。结论祛风活血解郁法对治疗MOH有一定的临床疗效,能明显改善患者的生活质量,效果并不劣于盐酸氟桂利嗪,且对郁证评分的改善优于氟桂利嗪。更多还原

【Abstract】 Objective To observe the clinical effect of the therapy of expelling wind, promoting blood circulation and resolving depression in treating medication-overuse headache(MOH). Methods Selected 60 migraine patients of MOH from the neurology department of hospital of Chengdu University of traditional Chinese medicine(TCM), from 2012/01 to 2014/10, were enrolled in the study. The patients were divided into treatment group(30 patients) and control group(30 patients) according to the random number table. All patients were treated with drug discontinuation and received MOH education. Diclofenace sodium or naproxen would be given if necessary. Patients in the treatment group were treated with Chaixiongzhitong decoction, while flunarizine hydrochloride in the control group. After the treatment for 3 months, to compared the severity and the lasting-time of headache, as well as the TCM syndrome evaluation score. Results The severity and the lasting-time of headache, as well as the TCM syndrome evaluation score declined in both two groups after the treatment, The difference was statistically significant(P<0.05); There was no significant difference of the severity and the lasting-time of headache between two groups,(P>0.05); Compared to the control group, the TCM syndrome evaluation score declined significantly in the treatment group(P<0.05), while the scores of the wind-syndrome and blood stasis-syndrome after treatment were not significantly different between two groups,(P>0.05). Conclusion The therapy of expelling wind, promoting blood circulation and resolving depression is effected in treating MOH, which could obviously improve the life quality of the patients. The clinical effect of this therapy is as good as flunarizine hydrochloride treatment, while it is better in improving the depression-syndrome score than flunarizine hydrochloride.更多还原