【摘要】 非受体酪氨酸激酶(NRTKs)能够将来源于细胞外受体接受的信号传递给细胞质内的其他蛋白或者是传递到细胞核,从而调节细胞的多种生理功能。其中,Src家族蛋白酪氨酸激酶(SFKs)作为一类重要的非受体酪氨酸激酶,在细胞的生长,分化,转移和生存中都有着重要的作用。其中,在肿瘤细胞的转移过程中,Src可以与整合素(Integrin)家族的不同亚型作用,介导不同的信号通路,从而影响细胞的运动性和转移性。在这篇综述中,将会对Src及其在肿瘤中的作用和靶向Src激酶的一些药物做一个简单的介绍。更多还原

【Abstract】 Non-Receptor Tyrosine Kinases(NRTKs) could transmit the signaling to the cytoplasmic proteins or to the nucleus,which are obtained from extracellular receptors, to regulate several physiological cellular processes. Src-family protein kinases(SFKs),as a series of important NRTKs, play an important role in cell growth, division, migration and survival signaling pathways. During the process of migration, Src could interact with different subtypes of Integrin to induce various pathways involved in cell mobility and migration. In this review, I would give a brief introduction of Src and its signaling in cancer, together with some Src kinase inhibitors.更多还原